Improved and Simplified Staining Technique for Dysplasia Detection in Colitis

A Prospective Trial Comparing Chromoendoscopy to a Digital Staining Technique and White Light in High Definition Colonoscopy in Patients With IBD Attending Scheduled Surveillance Colonoscopy

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06223347

Acronym

IST-DDC

Enrollment

106

Registered

2024-01-25

Start date

2024-01-31

Completion date

2026-04-30

Last updated

2024-01-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colitis, Colonic Dysplasia, Inflammatory Bowel Diseases, Colonoscopy, Surveillance

Brief summary

Comparing chromoendoscopy to a digital staining technique and White light in patients with IBD attending scheduled surveillance colonoscopy

Detailed description

In this study we will attempt to compare dye based chromoendoscopy to WLI (white light), NBI( Narrow Band Imaging) and TXI( Texture and Colour Enhancement Imaging). High Definition Colonoscopy is used. We aim to compare all these dye/lights to each other and find the best and simplest method to help to diagnose dysplasia more efficient and easier.

Interventions

DIAGNOSTIC_TESTChromoendoscopy

Chromoendoscopy: is a dye based staining of colonic mucosa. NBI: is an optical image enhancing technology that allows a detailed inspection of vascular and mucosal patterns, providing the ability to predict histology during real-time endoscopy. TXI: is a digital technique that enhance texture and color of the tissues to be more visible.

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

\- Person schedules to IBD- surveillance colonoscopy.

Exclusion criteria

* Total Colectomy. * Not well prepared Bowel. BBPS under 2 at any segement. * Pregnancy.

Design outcomes

Primary

Measure	Time frame	Description
Dysplasia detection rate	90 minutes	Dysplasia detection rate for each staining technique

Secondary

Measure	Time frame	Description
Hyperplasia detection rate	90 minutes	Hyperplasia detection rate for each staining technique
Adenoma detection rate, ADR	90 minutes	Adenoma detection rate, ADR, for each staining technique
Bowel cleansing quality according to Bowel Boston Preparation Scale	90 minutes	—
Serious adverse events (significant bleedings and perforations)	90 minutes	—

Countries

Sweden

Contacts

Primary ContactNaz Mohammed Salih, Dr.

naz.mohammed.salih@vgregion.se+46720267227

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026