Polycystic Ovary Syndrome
Conditions
Brief summary
The purpose of this study is to investigate the effect of semaglutide in women with Polycystic Ovarian Syndrome(PCOS ) and determine potential therapeutic benefits.
Detailed description
The study mainly focused for the following objectives: To determine the effect of semaglutide on ovulation and menstrual regularity. To determine the effect of semaglutide on androgen levels, namely testosterone, sex hormone binding globulin, and changes in hirsutism. To determine changes in weight, body mass index (BMI), and Glycated Hemoglobin( HbA1c) with semaglutide therapy.
Interventions
DRUGSemaglutide
effectiveness of semaglutide in PCOS
Sponsors
Methodist Health System
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
* Age 18-45 * Body mass index(BMI) \> 30 * Diagnosis of PCOS * Normal thyroid stimulating hormone, prolactin, follicle-stimulating hormone (FSH), estradiol, and normal progesterone
Exclusion criteria
* Medications excluded: any hormone-containing contraceptive - oral contraceptive pills, Progesterone-only pill, depo-provera, oral provera, progesterone-containing intrauterine contraceptive device * Letrozole, clomiphene citrate, FSH therapy * Androgen receptor blockers * 5α reductase inhibitors * Insulin * Hysterectomy * Endometrial ablation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of appropriate weekly dose | 4 weeks | To access the compliances of the therapy |
| Number of days on therapy | 4 weeks | To access the persistence on Semaglutide |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| measure the Weight in kilograms | 4 weeks | To access the weight changes during therapy |
| Numbers of days with exercise changes | 4 weeks | To access the ability to do exercise during the therapy |
Outcome results
None listed