Surgery, Ulcerative Colitis
Conditions
Keywords
Ulcerative Colitis, energy requirements, ileoanal anastomosis, j-pouch
Brief summary
A prospective observational study to assess the energy needs of Ulcerative Colitis patients undergoing total proctocolectomy with ileoanal j-pouch anastomosis.
Detailed description
Total proctocolectomy with creation of ileoanal j-pouch anastomosis is the gold-standard surgical procedure for familial polyposis, for ulcerative colitis unresponsive to medication and for colitis associated with dysplasia requiring total colectomy. Patients postoperatively face difficulties in maintaining their physical condition and quality of life due to potential complications such as surgical, mechanical, inflammatory and functional disorders increasing the rates of malnutrition. Postoperative changes as regards anthropometric characteristics and nutritional status have not been fully elucidated. Therefore, the need arises to calculate the energy needs of patients with ileoanal j-pouch anastomosis, given the lack of corresponding data and the possible differentiation of energy needs from a similar group of patients undergoing colorectal surgery. Of particular interest is the body composition of ileoanal anastomosis patients, which has been studied very little ), and the extent to which their energy needs are met, given dietary restrictions both preoperatively and postoperatively. It is therefore necessary to determine the energy needs, as well as the degree of their coverage by the diet, of UC patients undergoing proctocolectomy with creation of ileoanal j-pouch anastomosis.
Interventions
DIAGNOSTIC_TESTIndirect Calorimetry
Resting energy expenditure measurement
Sponsors
Evangelismos Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Patients with ulcerative colitis and planned proctocolectomy with ileoanal j-pouch anastomosis surgery or patients who are to undergo subtotal colectomy. * Age over 18 years. * Written informed consent to take part in the study. * Speaking ability in Greek or English. * Able to get tested fasted;
Exclusion criteria
* Age under 18 years. * Existence of pregnancy. * Inability to breathe inside the indirect calorimetry mask for the time required for the measurement. * Use of medications that may affect body metabolism will be evaluated individually (e.g. cortico-steroids etc.)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Amount of resting energy expenditure (kcal/day) | Before surgery, 1 week postoperatively, 3 months postoperatively | To evaluate total energy needs of patients who undergo proctocolectomy with ileoanal j-pouch |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| IBDQ | Before surgery and 1 week after Surgery | Inflammatory Bowel Disease Questionnaires (IBDQ), a widely used questionnaire for HRQoL assessment in patients with inflammatory bowel diseases (IBDs) |
| Resting energy expenditure change (kcal/day) | 1 week postoperatively and 3 months postoperatively | Changes in daily energy expenditure after surgery compared to pre surgery assesment. |
| Bristol stool form scale, min: type 1 (hard solid stools, better outcome) - max: type 7 (liquid stools, worst outcome) | Before surgery, 1 week postoperatively, 6 months after surgery | Longitudinal changes in Bristol stool form scale score before and after surgery. |
| Post operative weight loss | 1 week postoperatively, 3 months postoperatively | Post operative weight loss will be assessed by measuring the post weight on the date of surgery and adjusting for the baseline weight in kg. |
| Post operative Energy intake. | 1 week postoperatively, 3 months postoperatively | Total energy intake measured in calories after surgery. |
Countries
Greece
Outcome results
None listed