Hypertension
Conditions
Keywords
hypertension, Exercise prescription, Intelligent information management, 6-min walking test (6MWT), Cardiopulmonary exercise test (CPET)
Brief summary
Obesity and lack of exercise are one of the reasons for high blood pressure. Exercise can reduce the risk of cardiovascular events by reducing weight and blood pressure. The precise formulation of exercise prescription by cardiopulmonary exercise test (CPET) can effectively control hypertension. Our research group has formulated 50 exercise prescriptions for hypertension population in the early stage, but how to further effectively implement them needs to be discussed. Based on the previous experience of undertaking the project Exercise Prescription for Hypertensive People of General Administration of Sport of the People's Republic of China, this research group discussed the important role of intelligent information management in the clinical effect evaluation and effective implementation of exercise prescription for hypertension; To explore the feasibility of making exercise prescription for hypertension based on 6-min walking test, and whether it is not inferior to or equivalent to the accuracy and effectiveness of making exercise prescription by CPET. The relevant results will lay a foundation for exploring the broader adaptation of hypertension exercise prescription to the population.
Detailed description
The 6-minute walking test (6MWT) has good universality and accessibility, and can be used as the basis for formulating exercise prescriptions. According to the consensus of Chinese experts on the application of clinical norms of the six-minute walking test, it is recommended to formulate individualized exercise prescriptions based on the average walking speed of 6MWT calculated from the six-minute walking distance (6MWD), but there is no relevant content about hypertension.
Interventions
BEHAVIORALCPET exercise prescription
Exercise mode: walk Frequency: 5 times/week
BEHAVIORAL6MWT exercise prescription
Exercise mode: walk Frequency: 5 times/week
BEHAVIORALRegular exercise
Regular exercise
Sponsors
Peking University People's Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
45 Years to 64 Years
Healthy volunteers
No
Inclusion criteria
* Overweight/obesity; Normal or normal high blood pressure after drug use; Grade 1 hypertension (whether taking medicine or not); Having sports habits; Sports risk is low and medium
Exclusion criteria
* ≥ grade 2 Hypertension; High-risk hypertensive patients; Malignant hypertension, secondary hypertension, etc; Serious arrhythmia, heart failure, acute myocardial infarction; Severe stroke, liver and kidney insufficiency; Physical dysfunction and failure to cooperate for various reasons; Unable to conduct CPET; The Types and doses of antihypertensive drugs is still in the process of adjustment
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Body mass index, BMI | through study completion, an average of 1 year | body mass index （kg/m\^2） |
| Systolic blood pressure, SBP | through study completion, an average of 1 year | systolic blood pressure (mmHg) |
| Diastolic blood pressure, DBP | through study completion, an average of 1 year | diastolic blood pressure (mmHg) |
| Heart rate, HR | through study completion, an average of 1 year | Heart rate (beats/min) |
| Pulse wave velocity, PWV | through study completion, an average of 1 year | pulse wave velocity |
| PWV | through study completion, an average of 1 year | pulse wave velocity |
| weight | through study completion, an average of 1 year | weight (kg) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| exercise hypertension | through study completion, an average of 1 year | yes/no |
| circadian rhythm of blood pressure | through study completion, an average of 1 year | Ambulatory blood pressure monitoring |
| anxiety | through study completion, an average of 1 year | Anxiety score using Generalized Anxiety Disorder (GAD-7). High GAD-7 scores significantly predicted worse state of anxiety: no anxiety,0-4 scores; mild anxiety,5-9 scores; moderate anxiety,10-14 scores; severe anxiety,15-21 scores. |
| depression | through study completion, an average of 1 year | Depression score using Patient Health Questionnaire-9 (PHQ-9). High PHQ-9 scores significantly predicted worse state of depression: no depression,0-4 scores; mild depression,5-9 scores; moderate depression,10-14 scores; severe depression,15-27 scores. |
| use of antihypertensive drugs | through study completion, an average of 1 year | Record dosage and numbers of antihypertensive drugs using questionnaires. |
| Blood lipids | through study completion, an average of 1 year | Triglyceride, total cholesterol, low-density lipoprotein cholesterol |
Contacts
Primary ContactYang Xi, Doctor
Outcome results
None listed