Emergence Agitation
Conditions
Brief summary
The goal of this clinical trial is to compare Efficacy of low dose propofol(0.5 mg/kg) vs placebo given at the end of sevoflurane anesthesia for prevention of emergence agitation in pediatric patient undergoing MRI scan. The main question it aims to answer is Can low dose propofol reduce the incidence of emergence agitation after general anesthesia? Participants will be given propofol 0.5 mg/kg or saline according to the allocated group at the completion of MRI scan
Interventions
DRUGPropofol
recieve propofol 0.5 mg/kg intravenously at end of sevoflurane anesthesia
DRUGNormal saline
recieve propofol 0.5 mg/kg intravenously at end of sevoflurane anesthesia
Sponsors
Khon Kaen University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Intervention model description
RCT
Eligibility
Sex/Gender
ALL
Age
1 Years to 8 Years
Healthy volunteers
No
Inclusion criteria
* Age 2-8 years * ASA class I or II ,who schedule for MRI scan under sevoflurane anesthesia
Exclusion criteria
* Developmental delay * Psychological and neurological disorders * Abnormal airway * Reactive airway disease * Allergy to propofol, egg product * Family history of malignant hyperthermia * Need iv sedative medication before induction * Obesity
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| incidence of emergence agitation | at 5,10,15,20,25,30 minutes after extubation |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Length of stay in post anesthetic care unit | 2 hours after extubation | — |
| Incidence of complication | 2 hours after extubation | Nausea or vomiting, airway obstruction, laryngospasm, desaturation and apnea |
| Use of rescue medication | 2 hours after extubation | use of ondansetron, atropine |
| Emergence time | 2 hours after extubation | duration of emergence |
Countries
Thailand
Contacts
Primary ContactSanthita Pimonbut, M.D.
Outcome results
None listed