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Evaluation of the Effectiveness of Home-Use Desensitizing Agents on Dentin Hypersensitivity

Evaluation of the Effectiveness of Home-Use Desensitizing Agents on Dentin Hypersensitivity

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT06216262
Enrollment
180
Registered
2024-01-22
Start date
2024-03-01
Completion date
2024-08-23
Last updated
2024-08-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dentin Sensitivity

Keywords

Arginine, Novamin, Propolis

Brief summary

Dentin sensitivity is one of the most common problems in society and affects the quality of life related to oral health. Agents such as toothpaste, mouthwash, and dental cream are home-type desensitizing agents used as the first step in the treatment of dentin hypersensitivity. A total of 180 individuals with dentin sensitivity will be included in the study and the individuals will be randomly divided into 6 groups. Individuals in the 1st Group will be given arginine-containing toothpaste, individuals in the 2nd Group will be given novamin-containing toothpaste, individuals in the 3rd Group will be given propolis-containing toothpaste, individuals in the 4th Group will be given casein phosphopeptide amorphous calcium phosphate-containing dental cream, and individuals in the 5th Group will be given mouthwash containing potassium nitrate. Classic toothpaste with 1450 ppm fluoride will be distributed to individuals in the control group, which is the 6th group. The Dentin Hypersensitivity Experience Questionnaire (DHEQ-15), consisting of 15 questions, will be used to evaluate dentin sensitivity. Visual Analogue Scale (VAS) will be used to determine the individual's pain score in dentin sensitivity, and the individual will be asked to score the intensity of pain experienced between 0-10 points. Finally, in the evaluation of dentin sensitivity, a single dentist will apply air to the cervix of the tooth from a distance of 1 cm for 1 second, and the Schiff Sensitivity Scale score will be determined through clinical examination. A score between 0 and 3 will be determined by the dentist according to the patient's response to the air stimulus. The effectiveness of the home-use desensitizing agents used in the treatment of dentin hypersensitivity was evaluated with DHEQ-15, VAS and Schiff Sensitivity Scale; Baseline, 4th and 8th week scores will be compared.

Interventions

OTHERControl group

Brushing teeth twice a day for 8 weeks

OTHERArginine

Brushing teeth twice a day for 8 weeks

OTHERNovamin

Brushing teeth twice a day for 8 weeks

OTHERPropolis

Brushing teeth twice a day for 8 weeks

Following the procedure in the control group, it is applied to the tooth surface once a day for 3 minutes before going to bed at night for 8 weeks

Following the procedure in the control group, mouthwash twice a day in the morning and evening for 8 weeks

Sponsors

Çanakkale Onsekiz Mart University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
Yes

Inclusion criteria

* Between 18-70 years old * General health condition is good * Individuals with sensitivity in 2 or more non-adjacent teeth

Exclusion criteria

* Pregnant or breastfeeding women * Advanced periodontal diseases * Chronic diseases that may affect the study results * Major oral pathologies * Use of anticonvulsant, antihistamine, antidepressant, sedative, tranquilizer medication * Use of desensitizing paste in the last 3 months * Individuals who have been treated for periodontal disease in the last 12 months

Design outcomes

Primary

MeasureTime frameDescription
Dentine Hypersensitivity Experience Questionnaire-15 (DHEQ-15)for 8 weeks (initially, 4 weeks and 8 weeks)Dentin Hypersensitivity Experience Questionnaire-15 (DHEQ-15) is a 7-point Likert scale form consisting of 15 questions used to evaluate dentin sensitivity, with answers ranging from 'strongly agree' to 'strongly disagree'.
Visual Analogue Scale (VAS)for 8 weeks (initially, 4 weeks and 8 weeks)VAS is a scale in which the individual evaluates the pain level between 0 (no hurt) and 10 (hurts worst).
Schiff Sensitivity Scalefor 8 weeks (initially, 4 weeks and 8 weeks)In the evaluation of dentin hypersensitivity, a single dentist will apply air to the cervix of the tooth from a distance of 1 cm for 1 second during a clinical examination and the Schiff Sensitivity Scale score will be determined. 0: subject does not respond to air stimulus 1. subject responds to air stimulus but does not request discontinuaiton of stimulus 2. subject responds to air stimulus and requests discontinuaiton or moves from stimulus 3. subject responds to the air stimulus, considers stimulus to be painful and requests discontinuaiton of the stimulus

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 6, 2026