Opioid Use
Conditions
Brief summary
The effective management of post-operative pain in the setting of bariatric surgery presents significant hurdles for both anesthesiologists and surgeons. The objective of this study was to assess the effects of opioid-free anesthesia (OFA) using the modified mulimix technique on the levels of plasma interleukin-2 (IL-2) and interleukin-6 (IL-6) as the primary outcome. Additionally, the study aimed to evaluate the duration of analgesia and the analgesic requirements within the first twenty-four hours after surgery.
Detailed description
Objectives: The effective management of post-operative pain in the setting of bariatric surgery presents significant hurdles for both anesthesiologists and surgeons. The objective of this study was to assess the effects of opioid-free anesthesia (OFA) using the modified mulimix technique on the levels of plasma interleukin-2 (IL-2) and interleukin-6 (IL-6) as the primary outcome. Additionally, the study aimed to evaluate the duration of analgesia and the analgesic requirements within the first twenty-four hours after surgery. Methods: 60 patients were systematically selected and randomly assigned to Group A (OFA) and Group B (Opioid-Containing Anesthesia, OCA), with the modified Mulimix technique employed. Serum samples were collected from all patients, both at the onset of the skin incision and after the surgical procedure. These samples were then used to assess interleukin-2 (IL-2) and interleukin-6 (IL-6) levels. Additionally, the post-operative analgesic consumption was documented.
Interventions
DRUGopioid-FREE anesthesia.
They received opioid-free anesthesia. These patients were provided a multimodal combination infusion. The administration of this infusion commenced at a dosage of 0.2 micrograms per kilogram per hour of dexmedetomidine. The Modified Mulimix cocktail, consisting of dexmedetomidine at a concentration of 10 ug/ml, Ketamine at a concentration of 2.5 mg/ml, and Lignocaine at a concentration of 20 mg/ml, was administered to a patient weighing 100 kg and if the weight is 110 Kg the rate will be increased by 10 percent, etc.,
DRUGopioid-CONTAINING anesthesia.
The process of inducing anesthesia included the injection of fentanyl at a dosage of 2 micrograms per kilogram during the induction phase. Additionally, morphine was administered at a dose of 0.03 milligrams per kilogram at the time of port insertion.
Sponsors
Zulekha Hospitals
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
20 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* both genders * aged between 20 and 50 years * patients fall under the American Society of Anesthesia (ASA) categories II-III * body mass index (BMI) ranging from 35-50.
Exclusion criteria
* patients who declined participation in the trial * pregnant women * patients who encountered challenges in communication that could potentially impede a dependable postoperative evaluation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| immunological response | 20 MONTHS | to detect the immunological response in the form of IL-2 and IL-6. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The analgesic duration and requirements in the first twenty-four hours postoperatively | 20 MONTHS | assessing the analgesic duration and requirements in the first twenty-four hours postoperatively |
| comparing the Visual Analog Score | 20 MONTHS | comparing the Visual Analog Score between opioid-free anesthesia and opioid-contained. anesthesia. scale values from 0 to 100. from 0 to 4 considered no pain |
| The Non-Invasive blood pressure at baseline, 2 hours, 4 hours, 6 hours, 12 hours and 24 hours. | 20 MONTHS | investigating the changes in blood pressure associated with the two different anesthetic techniques to determine the most suitable approach for bariatric surgery. |
| Heart rate at baseline, 2 hours, 4 hours, 6 hours, 12 hours and 24 hours. | 20 MONTHS | investigating the changes in heart rate associated with the two different anesthetic techniques to determine the most suitable approach for bariatric surgery. |
Countries
Egypt
Outcome results
None listed