Serpin C and Soluble Fms-like Tyrosine Kinase-1 Levels in Normotensive Pregnant Women May Predict the Development of Preeclampsia

Deregulated Serum Levels of Serpin C and Soluble Fms-like Tyrosine Kinase-1 Might Predict the Development of Preeclampsia in Normotensive Pregnant Women

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06214702

Enrollment

Registered

2024-01-22

Start date

2023-01-07

Completion date

2023-11-15

Last updated

2024-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pre-Eclampsia

Brief summary

Evaluation of the predictability of estimated levels of Serpin C, sFlt-1 and placental growth factor (PLGF) in blood samples obtained during the 1st trimester from normotensive pregnant women for identification of women liable to develop PE during the course of pregnancy.

Interventions

DIAGNOSTIC_TESTELISA

ELISA estimation of PLGF, sFlt-1 and Serpin C

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

25 Years to 45 Years

Healthy volunteers

Yes

Inclusion criteria

* Normotensive pregnant women had singleton fetus presenting during the 1st trimester * free of

Design outcomes

Primary

Measure	Time frame	Description
Role of Biomarkers in detection of GHTN	9 months	The predictability of serum biomarkers' levels estimated at enrolment for the development of GHTN.

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026