Pulmonary Embolism
Conditions
Keywords
pulmonary embolism, Computed Tomography, contrast materials
Brief summary
The investigators aimed to compare the image quality and diagnostic performance of DECTPA using lower concentration iodine contrast materials and using normal concentration iodine contrast materials in the evaluation of suspected pulmonary embolism.
Detailed description
All patients met the inclusion and exclusion criteria will be given written informed consensus. The enrolled patients will randomly receive one of the three injection protocols: A: 30mL Iomeprol (Iomeron 300, Bracco Imaging, Milano, Italia) injected at a flow rate of 4mL/s; B: 50mL Iomeprol (Iomeron 300, Bracco Imaging, Milano, Italia) injected at a flow rate of 4mL/s; C: 50mL Ioversol (Ioversol 350, Hengrui, Jiansun, China) injected at a flow rate of 4mL/s. A and B groups are both lower concentration iodine contrast material groups, with different total iodine loads.
Interventions
DIAGNOSTIC_TESTLower concentration and lower volume contrast agent group
CT images using lower concentration and lower volume contrast material
Sponsors
Wuxi People's Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* Age greater than 18 years old * Clinical suspicion of pulmonary embolism suggests CTPA examination (Wells score\>4 or D-2 polymer elevation) * Patient's general physical condition tolerates CTPA examination
Exclusion criteria
* Allergy to iodine contrast agents * Hyperthyroidism * Pregnancy * Weight greater than 80kg * Heart failure patients, NYHA heart function level III or IV
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| image quality evaluation of the CTPA images of 30% participants | through the CTPA examinations of 30% participants finished,, an average of six month | 1. the mean CT number (in Hounsfield units) in the main pulmonary artery by using a region of interest of at least 1 square centimeter. 2. the CT number (in Hounsfield units) of peripheral pulmonary arteries close to the beginning and the end of each scan in a egmental or subsegmental artery at an apical and a basal section position. Because the caliber of the peripheral vessels was too small to reliably set an intraluminal region of interest to determine the mean CT number, the maximum CT number as a proxy for vascular attenuation should be chosen. 3. the images quality score for making a diagnosis other than PE ( using a five-point scale ranging from 1 to 5). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| overall diagnostic performance for pulmonary embolism | CTPA examinations all participants are finished, an average of two month | diagnostic accuracy, sensitivity and specificity |
Countries
China
Contacts
Primary ContactXiangming Fang, Doctor
Outcome results
None listed