Infertility
Conditions
Keywords
Infertility, IVF-ET, Poor ovarian responders, Double stimulation
Brief summary
The aim of this randomized controlled trial is to compare the efficacy and cost-effectiveness of using progestin with GnRH antagonist to prevent premature LH surge in poor responders undergoing double stimulation protocol.
Interventions
DRUGProgestin primed ovarian stimulation
HMG ( 300IU) was used during the follicular phase of ovarian stimulation (FPS) and during the luteal phase of ovarian stimulation (LPS). Progestin (dydrogesterone) 30 mg/day was used to prevent premature LH surge during the FPS and LPS.
DRUGGnRH antagonist
HMG ( 300IU) was used during the follicular phase of ovarian stimulation (FPS) and during the luteal phase of ovarian stimulation (LPS). Flexible GnRH antagonist protocol (Cetrorelix acetate) (0.2 mg) was used to prevent premature LH surge during the FPS and LPS.
Sponsors
Bedaya Hospital
Cairo University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
35 Years to 44 Years
Healthy volunteers
No
Inclusion criteria
Patients belonging to Poseidon group 4
Exclusion criteria
* PCOS * Endometriosis * History of recurrent abortion
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Medications costs per retrieved oocyte | Ten to fifteen days after starting ovarian stimulation] | Total cost of medications used in all cycles/number of retrieved oocytes |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Clinical pregnancy rate | 5 weeks after embryo transfer] | Presence of intrauterine gestational sac detected by transvaginal ultrasound |
| Ongoing Pregnancy Rate | 18 weeks after embryo transfer] | Pregnancies continued beyond 20 weeks gestation |
Countries
Egypt
Contacts
CONTACTUsama M Fouda, Prof.
PRINCIPAL_INVESTIGATORSamar A Alhofy, M.D, Msc
Cairo University
Outcome results
None listed