Autonomic Dysreflexia, Spinal Cord Injuries, UDS Filling Speed
Conditions
Brief summary
In patients with spinal cord injury, the investigators want to understand and understand the differences in AD prevalence and characteristics according to bladder injection rate, and to determine which factors have a greater influence between bladder expansion or injection rate.
Detailed description
It has been reported that there is a difference in the degree of AD between the bladder and urinary tract motility tests, suggesting a potential difference according to the injection rate. According to Liu et al., the authors noted that stimulation of the urethra, prostate, and internal sphincter appears to induce AD more strongly than the injection rate. In addition, the two main factors contributing to AD among urinary kinetics tests are the patient's age and bladder maximum urination pressure. Considering these factors is important in preventing AD during urinary kinetics tests. Despite these previous studies, the prevalence and severity of AD according to the injection rate of urinary kinetics tests in SCI have not been quantitatively evaluated.
Interventions
OTHERUrodynamic test
Urodynamic testing is performed using saline solution at the same temperature as body temperature (37 degrees) at two injection speeds of 10 mL/min and 100 mL/min, respectively.
Sponsors
Pusan National University Yangsan Hospital
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
1. Patients with chronic spinal cord injury 6 months after receiving the award 2. Patients with confirmed AD due to bladder fullness in previous urodynamic test 3. Patients confirmed to have neurological damage level C1-T6, AIS A or B
Exclusion criteria
1. Patients who cannot perform the test because their systolic blood pressure remains at 150 mmHg during the urodynamic test 2. Patients who cannot undergo testing due to hemodynamic instability 3. Patients who cannot undergo testing due to overt urinary tract infection
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Bladder volume (ml) | Immediately after the test | (1) at first AD at an infusion rate of 10 mL/min (2) at first AD at an infusion rate of 100 mL/min |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Bladder compliance (mL/cmH2O) | Immediately after the test | Bladder compliance |
| Symptoms (Y/N) | Immediately after the test | Symptoms |
| Blood pressure (mmHg) | Immediately after the test | Blood pressure |
| Heart rate (bpm) | Immediately after the test | Heart rate |
Countries
South Korea
Contacts
Primary ContactSungchul Huh, Ph.D
Outcome results
None listed