Impact of Perioperative Body Composition Abnormalities on Patient Outcomes After Liver Transplantation

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06209775

Enrollment

996

Registered

2024-01-17

Start date

2015-01-01

Completion date

2022-12-31

Last updated

2024-01-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Body Composition, Liver Transplantation

Brief summary

Accumulating evidence suggests the prognostic significance of body composition in chronic diseases and neoplastic diseases. CT imaging-based body composition abnormalities are significantly associated with post-LT adverse outcomes including decreased quality of life (QOL), impaired graft regeneration and mortality. However, the perioperative changes in body composition and their potential clinical implications remain unexplored. The objective of this study is to systematically explore and clarify the correlation between body composition and the prognosis of liver transplant patients through dynamic peri-transplant mornitoring.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* Adult patients undergoing deceased donor liver transplantation (DDLT) for the first time.

Exclusion criteria

* Pediatric transplants * Re-transplants * Multi-organ transplants * Liver cancer patients with macrovascular invasion or distant metastasis * Patients who died within 30 days after transplantation

Design outcomes

Primary

Measure	Time frame
Postoperative mortality	2015.1.1-2022.12.31
Postoperative recurrence of liver cancer	2015.1.1-2022.12.31

Outcome results