Brain Fog, Concentration Ability Impaired, COVID-19, COVID-19 Pandemic, COVID Long-Haul, Fatigue, Memory Deficits
Conditions
Keywords
EEG, fMRI, MRI, functional MRI, brain fog, long COVID, fatigue, difficulty concentrating, memory difficulty
Brief summary
The novel coronavirus SARS-CoV-2 infection, COVID, continues to rage throughout the world with 115,000,000 confirmed cases and over 2,500,000 deaths (as of Mar 3, 2021). This translates to millions of people surviving COVID19 infection. While the lungs are ground zero, COVID tears through organ systems from brain to blood vessels. We are now beginning to see people recover but complain of ongoing problems, including lingering cognitive problems, depression, and anxiety. We have brought together 2 laboratories with complementary techniques including psychological testing and neuroimaging methods togethers with markers in the blood that may signal damage in the brain. A close look at these problems is timely and imperative if we are to understand the pathophysiology of 'COVID brain' and prepare for downstream problems.
Detailed description
The SARS-CoV-2 pandemic has been going on for over a year worldwide, with 115,000,000 confirmed cases and over 2,500,000 deaths (as of Mar 3, 2021). We are seeing people recover from the initial COVID infection with complaints of ongoing problems. An increasing number of people are complaining of cognitive deficits and depression/anxiety. Methodologically, we have brought together two laboratories studying neurocognitive impairment using an EEG, MRI, and behavioral approach as well as laboratory-based data. This study queries neuropsychological functions in individuals using a neuropsychological battery, EEG-based measures, functional MRI (connectivity) and structural MRI (gray and white matter volumes, myelin, micro-bleeds). In addition, we have preliminary data to show a continued increase in plasma cytokines in COVID survivors. Plasma isolated neuronal enriched extracellular vesicles (nEVs) showed an increase in amyloid beta, neurofilament light and pT181-Tau, all proteins associated with neurodegeneration. The overall aim is to determine the extent of cognitive, clinical, and neurological damage in people recovered from COVID.
Interventions
n/a there is no intervention in this observational study
Sponsors
San Francisco Veterans Affairs Medical Center
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* Our studies require some in-person visits to our research lab, located at 42nd Ave and Clement St in San Francisco. * Because this study includes an MRI, part of the screening process will be to ensure you don't have any metal in your body, you do not have head or neck tattoos, and you are comfortable inside the MRI scanner. * 18-70 years with a confirmed COVID infection at least 3 months ago. * Negative metal screen for MRI safety * Normal (or corrected to normal) vision
Exclusion criteria
* Past or present neurological problems (including seizures and head trauma resulting in neurological or cognitive symptoms) * Loss of consciousness (LOC) greater than 30 minutes or any LOC with neurologic symptoms * Major medical conditions (e.g., seizures disorders, treatment with anticonvulsant medication, endocrine disorders, significant cardiac pathology) * Substance dependence, within the past year, or failed urine toxicology on the day of neuroimaging sessions * Known claustrophobia * Current pregnancy * IQ estimate \< 70
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change of Neuropsychological Test Performance | 1 month | We will compare NP test performance in people with Covid-related worsening of attention, memory, anxiety, and/or depression to people who do not endorse worsening in those domains. |
| Number of Participants with EEG Latency & Amplitude | 1 month | We will compare EEG-derived event related potential measures of neural speed in people with Covid-related worsening of attention, memory, anxiety, and/or depression to people who do not endorse worsening in those domains. |
| Number of Participants with MRI Functional Disconnectivity | 1 month | We will compare thalamo-cortical connectivity in people with Covid-related worsening of attention, memory, anxiety, and/or depression to people who do not endorse worsening in those domains. |
| Number of Participants with Blood Biomarkers | 1 month | We will correlate blood biomarkers of inflammation and NP test performance, thalamo-cortical connectivity, and measures of neural speed. |
Countries
United States
Contacts
Primary ContactKaitlyn L Dal Bon, BA
Backup ContactKen Lau, BS
Outcome results
None listed