Contralateral R1 in Amyotrophic Lateral Sclerosis

Evaluation of Contralateral R1 Component of the Blink Reflex in Patients With Amyotrophic Lateral Sclerosis

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06206629

Acronym

MOTOBLINK

Enrollment

120

Registered

2024-01-16

Start date

2024-02-15

Completion date

2024-09-05

Last updated

2024-10-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Amyotrophic Lateral Sclerosis

Keywords

Amyotrophic lateral sclerosis, ALS, Electroneuromyography, ENMG

Brief summary

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease affecting both upper and lower motor neurons. Electroneuromyography is an important tool for the diagnosis. Previous studies have shown that different components of the blink reflex, such as the latencies of homo- and contralateral R2 responses can be affected. Studies have found that a contralateral R1 component can appear in neurological diseases with affection of the central nervous system especially upper motor neuron, such as HTLV1 infection. Thus, you aim to determine if a contralateral R1 component could be present in ALS.

Interventions

DIAGNOSTIC_TESTblink reflex evaluation

A blink reflex evaluation will be performed in all subjects

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 99 Years

Healthy volunteers

Yes

Inclusion criteria

For patients * Aged 18 to 99 years old * Referred for suspected motor neuromuscular disease * Collection of non-opposition For healthy subjects: * Aged 18 to 99 years old * Absence of any neurological pathology * Collection of non-opposition

Exclusion criteria

* Previous damage linked to another cause of the cranial nerves * Prior brainstem lesions * Persons deprived of liberty by a judicial or administrative decision * Patient under judicial protection, unable to express consent

Design outcomes

Primary

Measure	Time frame	Description
Presence of a contralateral R1 component on blink reflex evaluation.	Day 1	A blink reflex evaluation will be performed in all subjects : Blink reflex will be recorded with surface electrodes placed medially over the lower part of the eyelid, on the orbicularis oculi muscle, with a reference electrode 2 cm laterally. Stimuli will be delivered to the supraorbital nerve by surface electrodes with an intensity required to generate a consistent homolateral R1 response. A contralateral R1 component will be defined as an early compound muscle action potential recorded in the contralateral orbicularis oculi muscle.

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026