Pilonidal Disease, Pilonidal Sinus
Conditions
Keywords
Platelet rich plasma(PRP), Pilonidal sinus surgery, Healing time
Brief summary
Our study was planned as a prospective controlled randomized study. The study was started after the ethics committee approval received from Dışkapı Yıldırım Beyazıt Training and Research Hospital. (23.08.2021 118/01). Two groups of patients were planned in parallel. In the treatment of pilonidal sinus disease, in patients operated on with the fistulotomy and curettage technique, one group was followed up with classical dressing, while the other group was followed up with PRP (platelet-rich-plasma) and classical dressing. Wound infection, hematoma, length of hospital stay, recurrence, pain in the first postoperative week, and time to complete epithelialization of the wound (in days) were evaluated between the two groups.
Detailed description
Our study was planned as a prospective controlled randomized study. The study was started after the ethics committee approval received from Dışkapı Yıldırım Beyazıt Training and Research Hospital. (23.08.2021 118/01). Two groups of patients were planned in parallel. In the treatment of pilonidal sinus disease, in patients operated on with the fistulotomy and curettage technique, one group was followed up with classical dressing, while the other group was followed up with PRP (platelet-rich-plasma) and classical dressing. Wound infection, hematoma, length of hospital stay, recurrence, pain in the first postoperative week, and time to complete epithelialization of the wound (in days) were evaluated between the two groups. A total of 140 patients, male and female, diagnosed with pilonidal sinus disease in our hospital between November 2021 and November 2022 were included in the study. Patients with acute pilonidal sinus abscess were excluded from the study, but chronic PS(pilonidal sinus) patients who had previously undergone abscess drainage were included in the study. Patients under 18 years of age, relapsed patients, anemic patients (Hg \< 10 mg/dl), thrombocytopenic patients (Plt˂10⁶/ml), patients with a history of radiotherapy-chemotherapy, patients with diabetes and patients using steroids were excluded from the study. Randomization was performed using the PASS computer program, and according to this randomization, fistulotomy and curettage technique (n=70) was applied to one group and fistulotomy and curettage + PRP (n=70) was applied to the other group. Demographic information, family history, smoking, presence of abscess drainage, post-drainage antibiotic use, comorbidities, BMI, symptom duration, phenol application, laser epilation, number of sinus pits, presence of secondary orifice, basal PLT(platelet) count, size of the defect after sinus excision, wound infection, hematoma, length of hospital stay, presence of recurrence, pain in the first postoperative week, and time to complete epithelialization were evaluated.
Interventions
OTHERPlatelet rich plasma
After application of platelet rich plasma after surgery, the patients have examined for infection, hematoma, pain, recurrence and the time of epithelialization of the wound.
Sponsors
İsmail Oskay Kaya
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Caregiver)
Eligibility
Sex/Gender
ALL
Age
18 Years to 59 Years
Healthy volunteers
Yes
Inclusion criteria
* patients diagnosed with pilonidal sinus disease in our hospital between November 2021 and November 2022
Exclusion criteria
* Patients under 18 years of age * Acute pilonidal abcess * Recurrent disease * Anemic patients (Hg \< 10 mg/dl) * Thrombocytopenic patients (Plt˂10⁶/ml) * Patients with a history of radiotherapy-chemotherapy * Diabetes Mellitus * Patients using steroids
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Platelet rich plasma accelerate the epithelialization of the wound after pilonidal sinus surgery | up to two months | After the application of PRP the patients examined at the postoperative 2-4-6-10-15-20-25-30-35-40-45-50-55 days for the wound closure. The day of total epithelialization was noted. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| infection | up to two months | presence of infection after surgery. |
| hematoma | up to two months | presence of hematoma after surgery. |
| Pain intensity | up tp two months | Pain intensity of patients measured by Visual analogue scale (VAS) score. 0 represents no pain and 10 pain as bad as it could possibly be |
| recurrence | up to two months | Recurrence of the pilonidal disease of the patient is presence of pits in the previous surgical area and also presence a tender mass or sinus draining mucoid, purulent, and/or bloody fluid |
Countries
Turkey (Türkiye)
Outcome results
None listed