Postoperative Recovery, Remazolam Anesthesia
Conditions
Brief summary
to investigate the effect of remazolam benzenesulfonate in patients with ocular fundus surgery, so as to guide clinical anesthesiologists to choose more appropriate anesthetic drugs in fundus surgery
Detailed description
to investigate the effect of remazolam benzenesulfonate in patients with ocular fundus surgery, so as to guide clinical anesthesiologists to choose more appropriate anesthetic drugs in fundus surgery。There are three groups.In Group H, ciprofol + Remifentanil was used for maintenance of anesthesia, in Group R, remifentanil + Remifentanil was used for maintenance of anesthesia, in Group RF, remifentanil + Remifentanil was used for maintenance of anesthesia, at the end of the operation, flumazenil was used to counteract the residual anesthetic effect.The quality of postoperative recovery was compared
Interventions
DRUGciprofol
sedation
DRUGRemazolam
sedation
DRUGFlumazenil
antagonism
DRUGRemifentanil
2ug/kg Remifentanil
Sponsors
Sichuan Provincial People's Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SCREENING
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
1. ASA I-II, patients 2. aged 18-65 years old; 3. Fundus surgery to be performed under general anesthesia ; 4. The expected duration of surgery is about 30-120 min ; 5. BMI: 18-30 kg/m2 ; 6. Those who signed the informed consent form and volunteered to participate in this trial
Exclusion criteria
1. Patients with known or suspected genetic susceptibility to malignant hyperthermia; 2. Patients with history of asthma; 3. Patients with severe heart diseases (NYHA ≥ III, severe arrhythmia, etc.) and cerebral or pulmonary diseases, liver or kidney dysfunction; or with unstable vital signs; 4. Patients with history of long-term narcotic analgesics application, including sedative and antidepressant drugs; 5. Patients with history of psychotropic drug abuse within 3 months; 6. Patients with long-term alcohol abuse; 7. People with mental disorder and unable to communicate normally;
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| time for recovery | 3 second to 30minutes | The time from stopping the anesthetic to waking up |
Contacts
Primary ContactYanYu Liu
Outcome results
None listed