Hypoxia, Altitude
Conditions
Keywords
inflammation, oxidative stress, intestinal damage, muscle damage, mitochondrial metabolism, normobaric hypoxia, training
Brief summary
* Cognitive assessment of the influence of a 4-week proprietary training program under normobaric hypoxia conditions on the levels of inflammatory markers, disturbances in prooxidant-antioxidant balance, degree of intestinal damage, and mitochondrial energy production rate in young sedentary males. * Applied objective: Development of practical training guidelines utilizing training in normobaric hypoxia conditions to enhance mechanisms related to oxygen transport, adaptive changes within the immune system, body's antioxidant capacity, gut permeability, substrate utilization efficiency, and mitochondrial function for coaches and athletes.
Interventions
Participants will engage in interval training and will reside and sleep at different altitudes for a period of 4 weeks. Aerobic and anaerobic capacity tests and an eccentric exercise test will be performed before and after the training intervention. Before and after the training program, somatic measurements will also be taken. Before and after the first and last workout, blood will be drawn for biochemical analysis.
Sponsors
Ministry of Education and Science,Poland
University School of Physical Education, Krakow, Poland
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
19 Years to 29 Years
Healthy volunteers
Yes
Inclusion criteria
* no known metabolic diseases, no contraindications to physical exercise and no history of high altitude sickness stated in interview. A medical examination (including ECG, blood and urine tests) is required.
Exclusion criteria
* changes in diet during the experiment, smoking and abuse of alcohol and/or other stimulants.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Measurement of aerobic capacity (endurance) | 7 days before training and 7-10 days after the training. Training will last 4 weeks. | Measurement of maximal oxygen uptake and determination of ventilatory thresholds (ergospirometry) |
| Measurement of anaerobic capacity | 7 days before training and 7-10 days after the training. Training will last 4 weeks | Measurement of maximal anaerobic power (Wingate Anaerobic Test) |
| Blood analysis | 7 days before training and 7- 10 days after the training. The training will last 4 weeks and will consist of 12 workouts. | Indicators of prooxidant-antioxidant imbalance, markers of inflammatory status, markers of muscle damage, markers of intestinal damage, HIF (hypoxia-inducible factor), EPO (erythropoietin), markers of mitochondrial metabolism, morphology (including reticulocytes). |
| Somatic indices | 7 days before training and 7-10 days after the training. Training will last 4 weeks. | Body composition analysis ( body height \[m\], body mass \[kg\], Quetelet II Index \[kg/m\^2\], lean body mass \[kg\], fat mass \[kg\], fat percentage \[%\] and total water content \[kg\] |
Countries
Poland
Contacts
Primary ContactAnna Radoń, MSc
Backup ContactAnna Kałuża, MSc
Outcome results
None listed