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Evaluation of the Diaphragm Performance During Weaning From Mechanical Ventilation

Evaluation of the Diaphragm Tissue Doppler Parameters in Predicting Weaning From Mechanical Ventilation Outcome

Status
UNKNOWN
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT06203353
Enrollment
50
Registered
2024-01-12
Start date
2023-11-01
Completion date
2024-12-30
Last updated
2024-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mechanical Ventilation Weaning

Brief summary

Prospective observationnal study, including ICU adult patients with invasive mechanical ventilation for at least 48 hours. Patients are included when performing weaning from mechanical ventilation with pressure support (lowest level of pressure support). Before separating the patient from the ventilator and performing a T tube spontaneous breathing test, diaphragm ultrasound is performed bilaterally : diaphragm excursion, diaphragm thickening fraction and maximal contraction and relaxation velocities with tissue doppler imaging.

Detailed description

This observationnal study will include patients during weaning from invasive mechanical ventilation: ventilation in pressure support with the lowest level With normal neurological status: glasgow coma scale \> 13 Requiring no vasopressor support conventionnal diaphragm parameters: diaphram excursion and thickening fraction will be collected bilaterally with the tissue doppler measures: maximal contraction and relaxation velocities, immediately before a T Tube test. Patients will be divided into 2 groups according to their weaning from mechanicla ventilation outcome, and diaphragm ultrasound patterns will be compared between the 2 groups in order to evaluate the performance of tissue doppler in predicting weaning outcome.

Interventions

DIAGNOSTIC_TESTdiaphragm ultrasound monitoring

Ultrasound measure the diaphragm excursion, thickening fraction and maximal contraction and relaxation velocities

Sponsors

Mongi Slim Hospital
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Invasive mechanical ventilation for at least 48 hours

Exclusion criteria

* reintubation for extra respiratory failure (neurologic or hemodynamic) * Patients with chronic repiratory failure

Design outcomes

Primary

MeasureTime frameDescription
weaning from mechanical ventilation successDay 2no need of non invasive ventilation or reintubation

Countries

Tunisia

Contacts

Primary ContactMhamed Mebazaa, professor
msmebazaa@gmail.com22252589
Backup ContactAsma Ben Souissi, Asso Prof
bsouissiasma@gmail.com98336883

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026