Atrophic Gastritis
Conditions
Keywords
Atrophic Gastritis, Gastric Cancer
Brief summary
Despite declining incidence rates, gastric cancer (GC) ranks the fourth leading cause of cancer-related mortality and the fifth most common cancer worldwide, with the highest incidence reported in Eastern Asia. The 5-year overall survival rate of early GC exceeds 90%, which was well above advanced GC. Most intestinal-type GCs follow the Correa cascade-inflammation,atrophy, intestinal metaplasia (IM), dysplasia and subsequent carcinoma. The presence of gastric mucosal atrophy and intestinal metaplasia are important risk factors for GC. The purpose of this study was to investigate the incidence of GC attributed to atrophic gastritis in a region with high incidence of GC.
Interventions
OTHEREsophagogastroscopy (OLGA 0-Ⅰ)
Surveillance endoscopies at years 3-5.
OTHEREsophagogastroscopy (OLGA II)
Surveillance endoscopies at years 2-3.
OTHEREsophagogastroscopy (OLGA III-IV)
Surveillance endoscopies every year.
Sponsors
Shanghai Jiao Tong University School of Medicine
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Ability and willingness to participate in the study and to sign and give informed consent * Biopsies were collected based on the recommendation of updated Sydney system
Exclusion criteria
* under 18 or over 80 years old * history of gastrectomy * severe systemic diseases or malignancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| early gastric neoplasm | After the baseline endoscopy, participants were scheduled for surveillance endoscopies at years 3-5 for subjects with operative link on gastritis assessment (OLGA) 0-Ⅰ, at years 2-3 for subjects with OLGA II and 1 year for subjects with OLGA III-IV. | histological diagnosis of high-grade dysplasia, and adenocarcinoma. |
Countries
China
Outcome results
None listed