Cancer
Conditions
Keywords
EBV, Prospective study, Cancer
Brief summary
The goal of this prospective cohort study is to investigate the associations between Epstein-Barr Virus (EBV) antibody levels and the risk of overall and site-specific cancer types in Southern China. The main questions it aims to answer are: Question 1: In addition to the established EBV-associated cancer types, such as lymphomas, nasopharyngeal carcinoma, and stomach cancer, whether EBV is associated with other cancer types? Question 2: What's the cancer burden attributed to EBV in Southern China?
Detailed description
Growing molecular evidence suggests the involvement of EBV in various cancers, however, comprehensive epidemiological evidence is still lacking. In this study, researchers conducted a population-based prospective cohort study to investigate the associations between EBV antibodies and the risk of overall and site-specific cancer types in Southern China. All the participants underwent EBV antibody tests at enrollment and were subsequently followed up annually for cancer incidence, vital status, and immigration status. The primary objective of this study was to provide prospective evidence for the role of EBV in multiple cancers, shedding light on the etiology of a broad range of common EBV-associated cancers.
Interventions
OTHERDiagnostic test: EBV antibody tests
Participants underwent several EBV antibody tests, including VCA-IgA, EBNA1-IgA, etc.
Sponsors
Wuzhou Red Cross Hospital
Zhongshan People's Hospital, Guangdong, China
Sun Yat-sen University
Study design
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
30 Years to 69 Years
Healthy volunteers
Yes
Inclusion criteria
* Subject residents in Zhongshan or Wuzhou City; * Subject has no medical record of prevalent cancer; * Subject has psychical condition and well consciousness, and willingness to accept and cooperate with the study's follow-up procedures.
Exclusion criteria
* Subject has heavy cardiovascular, liver, or kidney disease; * Subject has prevalent cancer.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cancer incidence | 10 years | The primary outcome of the study was the diagnosis of any type of cancer. The cancer type for each participant was defined as their initial and primary cancer diagnosis. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| All-cause mortality | 10 years | The participants were followed up annually for cancer incidence, vital status and immigration status through the Cancer Registry, Death Registry, and Population Registry of local regions. |
Countries
China
Contacts
Primary ContactWei-Hua Jia
Backup ContactYong-Qiao He
Outcome results
None listed