Epilepsy in Children
Conditions
Keywords
Focal Epilepsy, Lesional Epilepsy, Nonlesional Epilepsy
Brief summary
Currently, mapping the epileptogenic zone is based on a comprehensive preoperative assessment involving clinical, imaging and electrophysiological examinations. To reduce the need for invasive stereoelectroencephalography (SEEG) explorations, electrophysiological and imaging methods have been developed, such as resting-state functional MRI (fMRI) coupled with electroencephalogram and arterial spin-labeling perfusion MRI (ASL-MRI). It has been published that these new methods enable precise delineation of the epileptogenic zone and better preparation for surgery. The aim is to determine whether, in children with focal lesional epilepsy, the combination of ASL-MRI-EEG and resting-state fMRI-EEG enables precise identification of the epileptogenic zone to be defined by SEEG, the current reference examination.
Interventions
OTHERSecondary data collection
clinical data
Sponsors
Imagine Institute
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
No minimum to 18 Years
Healthy volunteers
No
Inclusion criteria
* Be under 18 years of age on the day of inclusion. * Present with one of the following forms of epilepsy: * refractory focal lesional epilepsy * rare non-lesional epilepsy * Present abnormalities (spikes) on the intercritical EEG * Have been selected by the Epilepsy multidisciplinary staff. * In the case of refractory lesional epilepsy, be required to perform an EEG-video recording using intracranial electrodes (SEEG) as part of the pre-surgical workup. * Be affiliated to a health insurance scheme.
Exclusion criteria
* Requiring general anesthesia for MRI * Require sedation specifically for research * Have generalized epilepsy * Be deprived of liberty or under guardianship.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Determine whether, in children with lesional focal epilepsy, the combination of ASL-MRI-EEG and resting-state fMRI-EEG can accurately identify the epileptogenic zone to be defined by SEEG, today's gold standard. | 15 years |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Correlate cortical perfusion change on SL-ASMRI and BOLD signal abnormalities on resting-state fMRI | 15 years | — |
| Compare cortical perfusion abnormalities and resting-state fMRI based on EEG data in MRI. | 15 years | — |
| Correlate BOLD-MRI perfusion abnormalities with anatomical (DTI (tractography)) and functional (resting-state fMRI) brain connectivity abnormalities. | 15 years | — |
| Study the pathophysiology of resistant lesional epilepsies | 15 years | Measurements of perfusion in ASL-MRI (inter and/or percritical) and the BOLD effect in resting-state fMRI |
| Evaluate whether these data will eventually make it possible to reduce the frequency of intracranial EEG explorations (stereo EEG, subdural grids), with a view to replacing invasive deep electrodes in the future with multimodal MRI coupled to EEG in MRI. | 15 years | — |
| Improving understanding of the pathophysiology of rare non-lesional epilepsies | 15 years | — |
| Compare ASL-MRI and resting-state fMRI data coupled with EEG to the results of deep electrodes (intracranial EEG - SEEG), which are today's gold standard. | 15 years | — |
Countries
France
Contacts
Primary ContactNathalie Boddaert, Pr
Outcome results
None listed