Lung Transplant Failure
Conditions
Keywords
respiratory physiotherapy, lung donor, improve lung donor
Brief summary
The main objective of the project is to determine the variation of PaO2 / FiO2 (PaFi) after the use of mechanical insufflation-exsufflation (MI-E) or mechanical cough assistant in the donor in brain death (DBD) and in the potential donor in control donor after circulatory death (cDCD) It is a randomized prospective multicentre study. Four centres with a solid organ donation program will participate in the study, the Hospital Clínic i Provincial de Barcelona (HCB), the Germans Tries y Pujol Hospital (HGTP), the Marqués de Valdecilla Hospital (HMV) and the Vall d'Hebron Hospital (HVH). One hundred and sixty consecutive eligible donors will be included in DBD and cDCD older than 18 years. * P1: Eighty donors will be maintained following national guidelines. * P2: Eighty donors will be maintained following national guidelines and: * Manual techniques of secretion drainage * Two sequences separated for 1 min of 6 cycles each of MI-E(Cough Assist E70, Respironics Philips. Demographic variables of the donor and recipient will be collected, as well as differences in PaFi, static compliance, and radiographic changes between P1 and P2 donors. The percentage of lung donors recovered by P2 with respect to P1 will be analyzed.
Interventions
DEVICEMIE
Two sequences separated for 1 min of 6 cycles each of MI-E(Cough Assist E70, Respironics Philips.
Sponsors
Hospital Vall d'Hebron
Germans Trias i Pujol Hospital
Hospital Universitario Marqués de Valdecilla
Vall d'Hebron Institute Research
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Organ donor older than 18yo
Exclusion criteria
* Absolute contraindications for MIE's use * Absolute contraindications for organ donation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The changes in Oxygenation | Ten minutes after the MIE application and 60 minutes after MIE application or national protocol aplication | The changes of oxygenation comparing MIE to national protocol |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Rate of complications with the use of MIE | During the intervention and 60 minutes after it. | To analyse the complications associated with the use of MIE in organ donors |
| Number of potential lung donors | during the recruitment time | To analyse the increase in potential lung donors with MIE |
| Number of lung donors | during the recruitment time | To analyse the increase in lung donors with MIE |
Countries
Spain
Contacts
Primary ContactIrene bello, Professor
Outcome results
None listed