Oligospermia, Sperm Count, Low
Conditions
Brief summary
This randomized controlled double-blind parallel-group interventional trial explores the impact of 8-week creatine supplementation, with or without ubiquinol, on sperm quality biomarkers in normospermic and oligospermic men. It aims to determine potential enhancements in sperm health to provide insights into male fertility and reproductive health improvement strategies.
Interventions
DIETARY_SUPPLEMENTSupplement 1
Creatine monohydrate (5 g/day)
DIETARY_SUPPLEMENTSupplement 2
Creatine monohydrate (5 g/day) plus ubiquinol (200 mg/day)
DIETARY_SUPPLEMENTPlacebo
Placebo (inulin)
Sponsors
University of Novi Sad, Faculty of Sport and Physical Education
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
MALE
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* Age 18 - 35 years * Sperm quality test available (at least half will have low sperm quality) * Informed consent * Healthy BMI (18.5 - 24.9 kg/m2)
Exclusion criteria
* Major chronic disease and acute injuries * History of dietary supplement use during the past 28 days * No consent to randomization * Participation in other studies
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Sperm concentration | Change from baseline sperm concentration at 8 weeks | Number of sperm per milliliter of semen |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Total antioxidant capacity | Change from baseline total antioxidant capacity at 8 weeks | Level of total antioxidant capacity in semen |
| Creatine kinase | Change from baseline creatine kinase at 8 weeks | Level of creatine kinase in semen |
| Creatine | Change from baseline creatine at 8 weeks | Level of creatine in semen |
| The World Health Organisation-Five Well-Being Index (WHO-5) | Change from baseline WHO-5 at 8 weeks | The World Health Organisation-Five Well-Being Index (WHO-5) is a short self-reported measure of current mental wellbeing.The raw scores are transformed to a score from 0 to 100, with lower scores indicating worse well-being. |
Countries
Serbia
Outcome results
None listed