Cardiac Amyloidosis in HFpEF Tunisian Patients

Prevalence of Cardiac Amyloidosis in Heart Failure Patients With Preserved Left Ventricular Ejection Fraction in Tunisia

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06201832

Acronym

Amy-Card

Enrollment

Registered

2024-01-11

Start date

2023-07-01

Completion date

2024-12-31

Last updated

2026-05-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bone Scintigraphy, Cardiac Amyloidosis, CMR, Diagnosis, Echocardiography, Heart Failure With Preserved Ejection Fraction, Prevalence

Brief summary

Cardiac amyloidosis (CA) has recently been reported as a common cause of heart failure with preserved left ventricular ejection fraction (HFpEF), with a prevalence of 6% in elderly HFpEF patients. However, the diagnosis of CA is still challenging and requires multiple costly investigations. Regardless of the type of CA, TTR or AL, early diagnosis significantly improves prognosis. In this study, the investigators aimed to determine the prevalence of CA in Tunisian HFpEF patients and to identify clinical and ultrasound criteria predictive of CA.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

60 Years to 90 Years

Healthy volunteers

Inclusion criteria

* HFpEF during the previous year * IVS thickness of 12mm or greater

Exclusion criteria

* age under 60 years * Acute coronary syndrome complicated by HFpEF * Congenital heart disease

Design outcomes

Primary

Measure	Time frame	Description
Prevalence of cardiac amyloidosis among HFpEF old Tunisian Patients	one year	Prevalence of cardiac amyloidosis in a Tunisian cohort of HFpEF patients aged 60 years or older with interventricular septal thickness equal to or greater than 12 mm

Secondary

Measure	Time frame	Description
Identify imaging criteria predictive of cardiac amyloidosis on CMR and echocardiography	one year	Number of cardiac amyloidosis patients with impaired global longitudinal left ventricular strain and/or impaired left atrial strain on echocardiography and/or elevated extra cellular volume (ECV) on CMR.
Frequency of different types of cardiac amyloidosis	one year	—

Countries

Tunisia

Contacts

PRINCIPAL_INVESTIGATORLilia Zakhama, Prof

University of Tunis El Manar, Faculty of Medicine of Tunis, Tunisia

Outcome results