Duodenal Diseases, White Spot Lesion
Conditions
Brief summary
With our study, we aimed to determine whether there is a correlation between zonulin, which plays a crucial role in intestinal barrier function and is implicated in the etiopathogenesis of many chronic and autoimmune diseases, and scattered white spots lesions associated with lymphatic stasis and inflammation in the duodenum.
Detailed description
During esophagogastroduodenoscopy (EGD), rarely encountered lesions in the duodenum present as scattered white spots (SWS) on the normal mucosa. Although not fully understood in terms of specific association with any particular disease and clinical significance, some studies have often observed chronic non-specific duodenitis (CND) and intestinal lymphangiectasia (IL) in lesions with SWS. This condition is thought to be related to lymphatic stasis. Patients included 63 individuals with identified SWS during EGD and 30 patients with a normal appearance of the duodenal mucosa were selected as the control group. SWS lesions were categorized into two groups, grade 1 and grade 2, based on the degree of density and endoscopic appearance. Biopsies were taken from the duodenum, antrum, and corpus. It was examined for IL, CND, giardiasis, and villous atrophy. Venous blood samples were collected from all patients for serum zonulin levels.
Interventions
DIAGNOSTIC_TESTsws grade 1
Blood for zonulin level was drawn from the group of patients with typical white lesions in the duodenum, called grade 1.
DIAGNOSTIC_TESTsws grade 2
Blood for zonulin level was drawn from the group of patients with typical white lesions in the duodenum, called grade 2
DIAGNOSTIC_TESTcontrol
Group of patients without scattered white lesions in the dueodenum on endoscopy.
Sponsors
Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* Patients with scattered white patchy lesions in the duodenum on endoscopy and control group patients with normal duodenum on endoscopy.
Exclusion criteria
* active gastroenteritis * acute kidney failure * chronic kidney failure * type-1 diabetes * inflammatory bowel disease * duodenal ulcer, * duodenal tumor * autoimmune diseases
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| zonulin levels | immediately after the procedure | Patients with scattered white spots in the duodenum had blood drawn for zonulin level immediately after the procedure. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Duodenal and gastric pathologic conditions | During the endoscopy | Biopsies from the duodenum and gastric antrum and corpus were taken during the endoscopy from patients with scattered white spots in the duodenum. |
Countries
Turkey (Türkiye)
Outcome results
None listed