Effect of Epidural Analgesia on Regional Lung Ventilation in Parturient Women as Assessed by Thoracic Impedance

Impact on Respiratory Function Associated to Epidural Analgesia in Parturient Women as Assessed by Electrical Impedance Tomography: a Monocentric Prospective Study

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06195774

Enrollment

100

Registered

2024-01-08

Start date

2024-01-31

Completion date

2026-12-31

Last updated

2024-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atelectasis, Pregnancy Complications

Keywords

pregnancy, labor, at term, electric impedance tomography, pulmonary impedance

Brief summary

The goal of this observational study is to learn more about the effect of obstetric epidural anesthesia on regional lung ventilation in healthy parturient women. The main question it aims to answer is whether the initiation or epidural analgesia improves or not regional lung ventilation in healthy women at term during labor. Participants will be subject to measurements of pulmonary impedance by electric impedance tomography before and after the start of epidural analgesia. No change will be applied to clinical care as a result of this measurement.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Healthy volunteers

Inclusion criteria

* At-term pregnancy (at least 36 weeks) * ASA class I-II

Exclusion criteria

* American Society of Anesthesiologists (ASA) Class III or more * BMI\>35 before pregnancy * Contraindication to routinely administrated drugs (levobupivacaine, lidocaine, sufentanil) * Contraindication to epidural analgesia * Pregnancy-related complications (including pre-eclampsia) * Respiratory system diseases * Severe psychiatric disorders * Twin pregnancy * Skin lesions in correspondence to the position of the Electric impedance tomography belt * Pacemaker or Implantable Cardioverter Defibrillator (ICD) * Language barrier

Design outcomes

Primary

Measure	Time frame	Description
Regional lung ventilation (ROI 1-4)	before measurements will be taken just before applying lumbar epidural analgesia, and after measurements will be taken 5 minutes and ten minutes after starting lumbar epidural analgesia. Measurements take 10 minutes of continuous registration	Assess regional ventilation as measured by electric impedance in each of the 4 Regions Of Interest (from anterior to posterior) in which the lung is divided, before and after epidural analgesia

Countries

Belgium

Contacts

Primary ContactStefano Doria, M.D.

stefano.doria@hubruxelles.be025558354

Backup ContactAlexandra Colesnicenco, M.D.

a.colesnicenco@hubruxelles.be025553919

Outcome results