Delirium
Conditions
Brief summary
To evaluate the relationship between abnormal protein or metabolite expression levels in peripheral blood and postoperative delirium in elderly patients undergoing cardiac surgery.
Interventions
None listed
Sponsors
Jining First People's Hospital
Study design
Observational model
OTHER
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
55 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
1. patients between 55 and 80 years old, 2. American Society of Anesthesiologists (ASA) physical status of II-III and New York Heart Association grade of II-III. 3. The planned cardiac surgery. 4. Hospitalization duration not less than 5 days. 5. The anesthesia time will be no less than 2 hours.All patients had a normal ability to hear, read and cooperate with neuropsychological tests.
Exclusion criteria
1. The pre-operative Montreal Cognitive Assessment (MoCA) score was less than 25, 2. Patients with dementia, history of neurological or psychiatric disease, hospital with anxiety depression scale (HADS) over eight points, 3. Currently use sedatives or antidepressants, Patients with substance dependence on drugs or alcohol. 4. Patients with liver and kidney dysfunction, patients with a history of cardiac surgery. 5. Admitted to the ICU for more than two days within the month preceding the current surgery, 6. Unable to cooperate with researcher's investigations.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Proteomics | 1 month | Proteomic data will be obtained by LC-MS/MS Analysis-DIA(Data Independent Acquisition) platform |
Countries
China
Contacts
Primary ContactFuhui Yan
Outcome results
None listed