The Prognostic Impact of Right Ventricular Systolic Dysfunction on the Survival of Patients With Sepsis and Septic Shock

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06193109

Enrollment

200

Registered

2024-01-05

Start date

2022-10-01

Completion date

2023-07-30

Last updated

2024-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sepsis and Septic Shock

Keywords

right ventricular systolic dysfunction

Brief summary

This study sought to evaluate the association of right ventricular systolic dysfunction and 28-day in-hospital mortality in patients with sepsis and septic shock. Prospective cohort study of adult patients admitted at Burapha university hospital from October 1, 2022 through June 30, 2023 for sepsis and septic shock, who had an echocardiogram within 72 hours after admission for evaluating right ventricular systolic function. Right ventricular systolic dysfunction was defned by the American Society of Echocardiography criteria. Outcomes included 28-day in-hospital mortality, maximal blood lactate, length of intensive care unit(ICU) stay and duration of mechanical ventilation.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* aged 18 years or older * diagnosed with sepsis or septic shock according to Sepsis-3 criteria * received an echocardiogram within 72 hours after admission

Exclusion criteria

* prior diagnosis of pulmonary hypertension, * cor-pulmonale, * significant valvular heart disease, * acute coronary syndrome, * aortic dissection, * heart failure * inability to follow up within 28 days

Design outcomes

Primary

Measure	Time frame	Description
28 days in-hospital mortality	October 1, 2022 and June 30, 2023	28 days in hospital mortality in patients with sepsis or septic shock

Secondary

Measure	Time frame	Description
The prevalence of right ventricular systolic dysfunction	October 1, 2022 and June 30, 2023	The prevalence of right ventricular systolic dysfunction in patients with sepsis and septic shock
Blood lactate levels	October 1, 2022 and June 30, 2023	Blood lactate levels in patients with sepsis and septic shock
Lenght of ICU stay	October 1, 2022 and June 30, 2023	Lenght of ICU stay in patients with sepsis and septic shock
Duration of mechanical ventilation	October 1, 2022 and June 30, 2023	Duration of mechanical ventilation in patients with sepsis and septic shock

Countries

Thailand

Outcome results