Ovarian Metastases of Colorectal Cancer
Conditions
Keywords
Krukenberg tumor
Brief summary
The study aimed to develop and validate models to predict survival outcome and key mutations in patients with ovarian metastases of colorectal cancer, as well as to compare the differential gene expression between long-survival group and short-survival group.
Detailed description
The investigator performed a retrospective-prospective cohort study with the aim of developing and validating comprehensive models to predict survival outcome and key mutations from multimodality data in patients with ovarian metastases of colorectal cancer. Secondly, the investigator aimed to compare the differential gene expression between long-survival group and short-survival group.
Interventions
OTHERPrediction model
We develop and validate clinical models to predict patient survival and gene signatures in ovarian metastases of colorectal cancer.
Sponsors
Sixth Affiliated Hospital, Sun Yat-sen University
Study design
Observational model
COHORT
Time perspective
OTHER
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* Histologically confirmed colorectal cancer * Unilateral or bilateral ovarian masses confirmed by peroperative imaging examination * Patient requiring resection of their ovarian and/or peritoneal carcinomatosis * 18 ≤ Age ≤ 85 * World Health Organization performance status ≤ 1 * Life expectancy \> 12 weeks * Adequate haematological, liver and renal function * Patient information and signature of the informed consent form before the start of any treatment procedures
Exclusion criteria
* Ovarian metastases of origin other than colorectal * Primary ovarian tumor * Clinical data missing
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Overall survival | At least 3-year follow up | Overall survival was defined as the time from surgery to death, or to the last follow-up. |
| Disease-free survival | At least 1-year follow up | Disease-free survival was defined as the interval between surgery and the first peritoneal or distant relapse or death from any cause. |
| Peritoneal-free survival | At least 1-year follow up | Peritoneal-free survival was defined as the interval between surgery and the first peritoneal relapse. Ovarian metastasis has been shown to be a subtype of peritoneal metastasis. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Rates of key gene mutation | At least 1-year follow up | Rates of key gene mutation, such as microsatellite instability-high/DNA mismatch repair |
Countries
China
Contacts
Primary ContactYuanxin Zhang, MD
Outcome results
None listed