18F-FDG, Hepatoblastoma, Neuroblastoma, Wilms Tumor
Conditions
Brief summary
the primary histologic origin of extracranial solid tumors in children is malignant embryonic cells, including Neuroblastoma (NB) , Hepatoblastoma(HB), and kidney, wilms' tumor(WT). Their main clinical symptoms are large abdominal masses, the most common lymph node metastasis . NB accounts for 15% of childhood cancer deaths, but some low-risk NB can disappear on its own. The International Neuroblastoma Risk Group Staging System (INRGSS) was used to determine Risk before NB treatment, whereas the INRGSS was entirely based on the Neuroblastoma diagnosis, illustrating the importance of imaging in the assessment of NB.18F-FDG is the most commonly used agent in PET imaging of tumor. It can reflect the glucose metabolism of tumor and is widely used in the diagnosis, staging, evaluation of curative effect and prognosis prediction of tumor In this study, the investigators retrospectively analyzed 18F-FDG PET/CT or PET/MRI images from patients with NB, HB, and WT. The investigators sought to assess whether these images provide useful information for diagnosis and prognosis.
Interventions
OTHERTelephone follow-up
Telephone follow-up
Sponsors
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
No minimum to 18 Years
Inclusion criteria
1. age \< 18 years, 2. have pathological results or definite clinical diagnosis as the gold standard.
Exclusion criteria
： 1. had surgery or chemotherapy before imaging, 2. accompanying other tumors, 3. diabetic patients or patients with fasting blood glucose ≥ 200 mg/dL.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Region of Interest (ROI) | up to 2 years | The presence of non-physiological uptake or uptake in a tissue structure can be considered pathological. The lesion intake is higher than the health organization and is classified as clearly positive. The lesion and the surrounding normal tissue ROI, measure the SUV, TLG and MTV. |
| Sensitivity and specificity of diagnosis and staging | up to 2 years | Comparison of the high uptake portion of a pet image suspected to be a histiocytoma for consistency with pathological findings, using the pathological section as the gold standard to calculate the sensitivity and specificity of the diagnostic. |
Countries
China
Outcome results
None listed