Adipokines, Glaucoma
Conditions
Keywords
Glaucoma；Adipokines；Neuroinflammation
Brief summary
The purpose of this study is to observe whether there are differences in adipokines in the aqueous humor between patients with primary open-angle glaucoma (POAG) and healthy controls
Detailed description
1\. Inclusion criteria: Patients aged 18 years or older, diagnosed with primary open-angle glaucoma (POAG) and healthy controls (who underwent cataract surgery). 2\. Exclusion criteria: 1. Other Ocular Diseases: Patients with concurrent ocular diseases such as macular degeneration, retinal detachment, etc., are excluded. 2. Ocular Surgery History: individuals who have undergone intraocular or laser surgery within the past 6 months, except for uncomplicated cataract surgery. 3. History of Ocular Trauma or Inflammation 4. Systemic Diseases or Mental Disorders: Patients with systemic diseases(e.g., diabetes, rheumatoid arthritis) and those with mental disorders are excluded. 5. Pregnancy or Lactation: Females who are pregnant or lactating are excluded. 6. Presence of any retinal or optic nerve disease other than glaucoma.
Interventions
OTHERnone intervention
This study has no intervention
Sponsors
Beijing Tongren Hospital
Peking University
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* Patients aged 18 years or older, diagnosed with primary open-angle glaucoma (POAG) and healthy controls (who underwent cataract surgery).
Exclusion criteria
* Other Ocular Diseases: Patients with concurrent ocular diseases such as macular degeneration, retinal detachment, etc., are excluded. * Ocular Surgery History: individuals who have undergone intraocular or laser surgery within the past 6 months, except for uncomplicated cataract surgery. * History of Ocular Trauma or Inflammation * Systemic Diseases or Mental Disorders: Patients with systemic diseases(e.g., diabetes, rheumatoid arthritis) and those with mental disorders are excluded. * Pregnancy or Lactation: Females who are pregnant or lactating are excluded. * Presence of any retinal or optic nerve disease other than glaucoma.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Concentration of adipokines in aqueous humor | Cross-sectional baseline | Aqueous humor samples were assessed for adipokines and inflammatory cytokines by Luminex bead-based multiplex array |
Countries
China
Contacts
Primary ContactZiyao Xia, M.D.
Backup ContactChun Zhang, Ph.D.
Outcome results
None listed