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Perioperative Blood Transfusion in Open Liver Resection

The Risk Factors for Perioperative Blood Transfusion in Open Liver Resection, a Retrospective Cohort Study Development of a Transfusion Scoring System to Predict the Requirement for Perioperative Blood Transfusion in Open Liver Resection

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT06189911
Enrollment
1201
Registered
2024-01-05
Start date
2006-01-01
Completion date
2023-01-01
Last updated
2024-03-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Blood Loss, Postoperative

Keywords

liver resection, risk factors, blood transfusion, scoring system

Brief summary

This observational study is specifically designed to identify the pre-operative risk factors that significantly contribute to perioperative packed red cell transfusions in open liver resection procedures. The main question it aims to answer are: 1. What are the risk factors of peri-operative blood transfusion in open liver resection procedures 2. What are the difference outcomes between patients who receive blood transfusion and the other group. Researcher will compare perioperative factor and post operative outcomes between transfused and non-transfused group

Detailed description

After approval of the study protocol from the institutional review board of Chiangmai University (Approval number: ANE-2564-08020), we performed a retrospective review of all patients who underwent an elective open liver resection in our specialized hepato-biliary center from January 2006 through December 2017. This retrospective inquiry comprised 808 patients. The data was systematically retrieved from electronic medical records. Baseline characteristics including age, gender, body mass index (BMI), co-morbidity, American Society of Anesthesiologists (ASA) classification, diagnosis, hepatitis profile, Child-Pugh classification, cirrhosis, the largest tumor size, previous liver resection, and pre-operative laboratory investigations were collected. The following intra-operative data were collected: type of liver resection, hilar resection, vascular reconstruction, volume and type of fluid administration, estimated blood loss, packed red cell and blood product transfusion, and operation time. The definitions of liver resection and the type of hepatectomy were aligned with the anatomic classification of the Brisbane 2000 Terminology

Interventions

The definitions of liver resection and the type of hepatectomy were aligned with the anatomic classification of the Brisbane 2000 Terminology

Sponsors

Chiang Mai University
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* All genders age above 18 year old who underwent open liver resection from 2006-2017 * Elective open liver resection

Exclusion criteria

* Patients who death during the course of a surgical operation

Design outcomes

Primary

MeasureTime frameDescription
the pre-operative risk factors of perioperative packed red cell transfusions in open liver resection procedures.the transfusion of packed red cells during the operation and 48 hours after surgerySignificant risk factors for perioperative blood transfusion were determined by factors with a p-value \< 0.05 derived from the multivariable logistic regression analysis. This analysis facilitated adjustments for potential confounders to identify the independent risk factors associated with perioperative blood transfusion

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026