Thymus Neoplasms
Conditions
Keywords
Thymus Neoplasms, Adjuvant Radiotherapy
Brief summary
The purpose of this study is to evaluate the efficiency and toxicity of adjuvant hypofractionation radiotherapy for thymic epithelial tumours after complete resection.
Detailed description
Adjuvant Radiotherapy(Postoperative radiotherapy) is proposed in stage II and III thymic carcinoma，stage III thymoma，stage IIB B2/B3 thymomas. Hypofractionation Radiotherapy is used in this study. The purpose of this study is to evaluate the efficiency and toxicity of adjuvant hypofractionation radiotherapy for thymic epithelial tumours after complete resection.
Interventions
RADIATIONAdjuvant Hypofractionation Radiotherapy
Adjuvant Hypofractionation Radiotherapy for Thymic Epithelial Tumours After Complete Resection
Sponsors
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
Adjuvant Hypofractionation Radiotherapy for Thymic Epithelial Tumours After Complete Resection
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Thymoma and Thymic carcinoma confirmed by histology or cytology * R0 resection (complete resection) * stage II and III thymic carcinoma，stage III thymoma，stage IIB B2/B3 thymomas. * Karnofsky performance status(KPS) 80, 90 or 100. * Having sufficient Pulmonary function, renal function and liver function. Neutrophile granulocyte count\>1.5×109 /L, platelet count\>80×109 /L, hemoglobin ≥10g/dL.
Exclusion criteria
* Prior thoracic radiotherapy. * Uncontrolled Comorbidities. * Pregnant or nursing mother. * Pneumonia
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Disease Free Survival | 2 years, 5 years | From the date of resection to the date of disease recurrence or death |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Overall Survival | 2 years, 5 years | From the date of resection to the date of death |
| RadiotherapyToxicity | 1 years, 2 years, 5 years | Rate of pneumonitis；Rate of esophagitis；Rate of skin reaction；Rate of myelitis；Rate of heart disease；Rate of vascular toxicity |
| local recurrence | 2 years, 5 years | recurrence of tumor bed |
| Intrathoracic recurrence / pleural metastasis | 2 years, 5 years | Rate of Intrathoracic recurrence / pleural metastasis |
| metastasis free survival | 2 years, 5 years | From the date of resection to the date of metastasis or death |
Countries
China
Contacts
PRINCIPAL_INVESTIGATORTao Zhang, Dr.
National Cancer Center/Cancer Hospital, CAMS
Outcome results
None listed