Pruritus Caused by Drug
Conditions
Keywords
morphine induced pruritus
Brief summary
the goal of this randomized clinical trial is to find the optimum sub hypnotic dose of iv propofol that prevents the incidence of itching induced from intrathecal morphine used in spinal anesthesia in caesarean section operation. the main questions it aim to answer are the number of patients complained of pruritus in the first 24 hours post operative period and the severity of the pruritus. participants will be divided into 4 groups. 1st group receives 0 mg of propofol , 2nd receives 10 mg , 3rd receives 20 mg and the 4th receives 30 mg.
Interventions
DRUGPropofol
trying different dosages of propofol 10mg/ml IV to determine the prophylactic dose for morphine induced pruritis
Sponsors
Assiut University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
1. The study is scheduled for women undergoing elective caesarean section under spinal anesthesia. 2. The subject is ≥ 20 years and ≤ 40 years. 3. No obvious abnormalities in preoperative ECG, blood routine, electrolytes, and other tests. 4. ASA class 1-2.
Exclusion criteria
* Patients who had a known allergy to propofol, morphine, or bupivacaine. * Those with preexisting pruritus caused by pregnancy, a coexisting skin disorder, or other pruritogenic systemic diseases. * Patients with a contraindication to spinal anaesthesia * Failed block * Need of extra sedation intra-operative * Positive history for asthma or COPD. * Patient refusal
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| number of participants complained of pruritus in the first 24hr post operative period | first 24 hours post operative period |
Contacts
Primary ContactSohila K Hassan, MBBCH
Outcome results
None listed