Carpal Tunnel Syndrome
Conditions
Keywords
carpal tunnel syndrome, hydrodissection, ultrasonography, median nerve gliding
Brief summary
Compare the efficacy on carpal tunnel syndrome (CTS) treatment between hydrodissection with hyaluronic acid (HA) vs 5% dextrose
Detailed description
Compare the efficacy on carpal tunnel syndrome treatment between hydrodissection with hyaluronic acid vs 5% dextrose through ultrasonographic evaluation.; 2) Evaluate the association of median nerve gliding results between using duplex Doppler ultrasound and B mode video with cross-correlation algorithm.
Interventions
PROCEDUREUltrasound guided median nerve hydrodissection injection with Hyaluronic acid
Hyaluronic acid was injected under ultrasound guidance around median nerve at the wrist
PROCEDUREUltrasound guided median nerve hydrodissection injection with Dextrose water
Dextrose water was injected under ultrasound guidance around median nerve at the wrist
Sponsors
Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Outcomes Assessor)
Masking description
Hyaluronic acid and dextrose are both transparent, which is prepare by technician who is not participate in intervention and assessment
Eligibility
Sex/Gender
ALL
Age
20 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* 20-80 years old patients with carpal tunnel syndrome
Exclusion criteria
* pregnancy, Diabetes, hypothyroidism, uremia, rheumatoid arthritis, coagulopathy, cervical radiculopathy and patients who has ever received surgery for carpal tunnel syndrome or wrist fracture
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Boston CTS (carpal tunnel syndrome) questionnaire | before injection , 2 weeks, 3 months and 6 months after injection. | The Boston CTS questionnaire is self-administered and is composed of two parts: the symptom severity scale (11 questions) and the functional status scale (8 questions).A final score is calculated for each scale (the sum of the individual scores divided by the number of items) and ranges from 1 to 5, with a higher score indicating a more severe handicap. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Ultrasonography (B mode) of median nerve | before injection , 2 weeks, 3 months and 6 months after injection. | Transverse ultrasonograms were obtained at the level of pisiform bone. Using electronic calipers, the CSA of the median nerve was measured by tracing the margin of the inner border of the perineural hyperechogenic rim that surrounded the hypoechoic median nerve , unit : mm2 |
| Ultrasonography (duplex Doppler) of median nerve | before injection , 2 weeks, 3 months and 6 months after injection. | An ultrasonography probe was placed longitudinally at the level of the lunate-capitate intercarpal joint to obtain a clear image of the median nerve. Longitudinal gliding excursions of the median nerve and flexor tendon were recorded using Doppler ultrasonography. The saved images were transferred to a personal coputer and analyzed by a researcher who was unaware of the individual and group identity of each image |
| Nerve conduction study (NCS) of median nerve | before injection , 3 months and 6 months after injection. | Distal motor latencies of the median and ulnar nerve were respectively measured by placing a stimulating electrode at the wrist and a recording electrode 8 cm away from the stimulating electrode on the abductor pollicis brevis muscle and the adductor digiti minimi muscle. For sensory NCSs of the median and ulnar nerves, a standard distance of 14 cm was maintained between the stimulating electrode at the wrist and the recording electrodes at the ring finger on radial and ulnar sides |
Countries
Taiwan
Contacts
Primary ContactYi Wei Chang, MD, MS
Outcome results
None listed