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Analgesic Efficacy of Ultrasound Guided Serratus Anterior Plane Block and Pectoral Nerve Block II

Analgesic Efficacy of Ultrasound Guided Serratus Anterior Plane Block and Pectoral Nerve Block II Compared to Thoracic Epidural Block After Unilateral Modified Radical Mastectomy

Status
UNKNOWN
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT06188156
Enrollment
99
Registered
2024-01-03
Start date
2023-02-01
Completion date
2024-02-28
Last updated
2024-01-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anesthesia, Radical Mastectomy

Keywords

thoracic epidural blockage, Ultrasound Guided Serratus Anterior Plane Block, Pectoral Nerve Block II, Radical Mastectomy

Brief summary

Modified Radical Mastectomy accounts for 31% of all breast surgeries and considered the fundamental surgical management for breast cancer. Nearly 40-60% of patients experience severe acute postoperative pain. This pain might persist for 6-12 months and result in post-mastectomy pain syndrome and complex regional pain syndrome (causalgia)

Detailed description

There are some local or regional nerve blocks in breast surgeries performed as core components of multimodal analgesia and enhanced recovery after surgery (ERAS), including thoracic epidural (TEB), interscalene brachial plexus, paravertebral, ultrasound-guided pectoral nerve block ( PECS II ), ultrasound-guided serratus anterior plane block (SAPB) and erector spinae plane block . Thoracic epidural (TEB) is the gold standard technique following breast surgery, but there is still a problem with the adequacy of thoracic and axillary blockage during lymph node dissection . Modified PECS's block or PECS block type II aimed to block the axilla that is vital for axillary clearances and the intercostal nerves, necessary for wide excisions which can provide analgesia after breast surgery. In the ultrasound-guided serratus anterior plane block (SAPB), the local anesthetic (LA) is injected in the compartment between the serratus anterior and latissimus dorsi muscles. SAPB anesthetizes the intercostobrachial nerve, lateral cutaneous branches of the intercostal nerves (T3-T9), long thoracic nerve, and thoracodorsal nerve thus providing analgesia for breast and lateral thoracic wall surgeries

Interventions

PROCEDUREAnethesia

To assess the effectiveness of thoracic epidural blockage versus ultrasonic guided PECS II block versus ultrasound guided serratus anterior plane block for postoperative pain management in modified radical mastectomy.

Sponsors

Al-Azhar University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender
FEMALE
Age
35 Years to 65 Years
Healthy volunteers
No

Inclusion criteria

* Women aged 35-65 years. * BMI 18.5 - 25 kg/m2. * American Society of Anesthesiologists (ASA) I-II.

Exclusion criteria

* Patient refusal. * Coagulopathy. * Mental and psychiatric disorders. * History of chronic pain. * Hypersensitivity or contraindication to any of study drugs * Previous chemotherapy.

Design outcomes

Primary

MeasureTime frameDescription
Measurement of Post-operative PainFirst 24-hour analgesic after MastectomyAssessment of the pain post-operatively in patients with pain assessed by VAS score : Total scores vary from 0 to 10 in this method, with a higher score indicating more severe pain

Countries

Egypt

Contacts

Primary ContactAhmed Elbasuni, MSC
ahmedelbasuni86@yahoo.com+201125373436

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026