Atheroscleroses, Cerebral, Carotid Plaque
Conditions
Keywords
carotid ultrasound., Carotid plaque-burden, atheroscleroses events prediction
Brief summary
Carotid ultrasonography has been proposed as a tool for prediction of future cardiovascular disease (CVD). Nevertheless, its role in clinical practice remains controversial. Methods: The investigators analyse the incidence of CVD and mortality in a cohort of 1004 participants without preexisting CVD according to a simple plaque scale recorded in different segments of the carotid artery assess by ultrasound. A prognostic tool for CV events was development adding Carotid Plaque-Burden (CPB) scale to the Systematic COronary Risk Evaluation (SCORE2) table (CPB- SCORE2 scale).
Detailed description
Based in number of plaques and stenosis a simple plaque scale was recorded in different segments of carotid artery, involving a cohort of 1004 participants with vascular risk factors. Outcomes were recorded during 14 years. A prognostic tool for CV events was development adding simple Carotid Plaque-Burden (CPB) scale to the SCORE2 table (CPB- SCORE2 scale).
Interventions
None listed
Sponsors
Fundación para la Formación e Investigación de los Profesionales de la Salud de Extremadura
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Any of these vascular risk factors: Total cholesterol \>200 mg/dL, hypertension, or diabetes, or receiving medication for them * No cardiovascular disease: coronary, cerebral o peripheral arterial disease.
Exclusion criteria
* Associated conditions: cancer, heart failure, chronic obstructive disease, renal insufficiency, neurodegenerative diseases, rheumatic diseases or chronic infections. * Neck anatomical barriers to perform ultrasound. * Enrolled in a clinical trial. * Attend \<70% of regular appointments
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Differences in rates of major adverse cardiovascular events (MACE) | 12 year follow-up | MACE: number of Major Adverse Cardiovascular Events; myocardial infarction, ictus or amputation or revascularisation of leg due to critical ischaemia |
| Differences in rates of all-cause death | 12 year follow-up | All-cause death: number of death from any cause |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Diagnostic value of Carotid Plaque-Burden-Systematic COronary Risk EvaluationSystematic COronary Risk Evaluation2 (CPB-SCORE2) table compared to Systematic COronary Risk Evaluation2 (SCORE2) for MACE | 12 year follow-up | Minimum and maximum values are 1 and 3, were higher scores mean a worse outcome. Sensitivity, Specificity, negative predictive value; positive likelihood ratio; negative likelihood ratio (%). net reclassification index;will be compared between High-Risk vs Low-Intermediate-Risk to PBS-SCORE2 table compared SCORE2. |
Outcome results
None listed