Prostate Cancer
Conditions
Brief summary
There has been literature demonstrating the effectiveness of correcting these MRI images by using an additional measurement of the magnetic field, but the implied improvement in lesion detection in these common distorted regions in the prostate has yet to be shown. We propose that introducing this distortion correction would greatly improve the DWI images used for tumour detection. For this study we propose testing this hypothesis as a primary objective, and as a secondary objective including additional b-values to further refine the ADC value. The study involves adding one additional distortion correcting scan to the standard clinical study, adding approximately 2 minutes to the study.
Interventions
DIAGNOSTIC_TESTMRI scan
MRI scan
Sponsors
Norfolk and Norwich University Hospitals NHS Foundation Trust
University of East Anglia
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
18 Years to 100 Years
Healthy volunteers
No
Inclusion criteria
* Male * Aged 18 and over * No contraindication to MR scanning * Smokers and non-smokers * Patients who have had a complete scan on the 3T scan MRI at Norfolk and Norwich University Hospital and have gone on to have a biopsy at the Norfolk and Norwich University Hospital
Exclusion criteria
* Previous diagnosis of prostate cancer, prostatic biopsy or treatment for prostate cancer
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| MRI image quality | 12 months | To determine whether correcting for the distortion in MRI images caused by rectal gas improves the image quality and thus diagnostic ability in localising and detecting prostate cancer |
Countries
United Kingdom
Contacts
PRINCIPAL_INVESTIGATORPaul Malcolm
Norfolk and Norwich University Hospitals NHS Foundation Trust
Outcome results
None listed