Nocturnal Enuresis, Enuresis, Enuresis, Nocturnal
Conditions
Brief summary
To determine whether there is a role for the selective serotonin reuptake inhibitors fluoxetine versus desmopressin in the treatment of nocturnal enuresis in children who have not responded to standard nonpharmacological urotherapy, and whether there are side effects involved.
Interventions
DRUGFluoxetine 20 MG
fluoxetine
DRUGDesmopressin
desmopressin
Sponsors
Fayoum University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
8 Years to 16 Years
Healthy volunteers
No
Inclusion criteria
1. Age ≥ 7 years 2. Severe enuresis with at least (50%) seven wet nights out of 14 3. Failed treatment 4. The enuresis alarm was either ineffective or considered impractical due to the family circumstances.
Exclusion criteria
1. Underlying renal, urologic, neurologic, endocrinologic, or cardiac conditions 2. Patients with psychiatric disorders and behavioral disorders including depression, attention-deficit/hyperactivity disorder. 3. Untreated constipation 4. Contraindications to fluoxetine or desmopressin treatment
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The children will be non-responders, partial responders, or full responders to therapy | three months | The standardization of terminology of lower urinary tract function in children and adolescents: Update report from the standardization committee of the International Children's Continence Society ICCS definitions (i.e., if the reduction of enuresis frequency was below or above 50% or 90%, respectively) |
Countries
Egypt
Outcome results
None listed