Overactive Bladder
Conditions
Brief summary
The objective of this study is to compare the effectiveness of mirabegron, solifenacin, tadalafil (5mg), and their combination in relieving symptoms of overactive bladder (OAB) in a double-blinded prospective randomized placebo-controlled trial.
Interventions
DRUGSolfenacin
pills taken once day
DRUGMirabegron
pills taken once day
DRUGTadalafil 5mg
pills taken once day
Sponsors
Elsayed Abdelhalim Elsayed
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Women from 18 to 65 years of age with LUTs due to OAB
Exclusion criteria
* Severe cardiovascular disorders. \\ * Severe neurogenic dysfunction. * Drug administration which interfere with bladder function . * Abnormal bleeding profile. * A verified urinary tract infection as determined by urinalysis and/or urine culture during screening
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| overactive bladder symptoms score (OABSS) | three months | OABSS is a symptom assessment questionnaire designed to quantify OAB symptoms into a single score The questionnaire consists of 4 questions on OAB symptoms with maximum scores ranging from 2 to 5: daytime frequency (2 points), night-time frequency (3 points), urgency (5 points), and UUI (5 points). The total score ranges from 0 to 15 points, with higher scores indicating higher symptom severity. |
Countries
Egypt
Outcome results
None listed