Presbycusis
Conditions
Keywords
presbycusis, aging, cognitive decline, speech in noise, sound localisation, hearing loss
Brief summary
This cohort study is expected to provide valuable insights into the complex interplay between auditory and cognitive functions and how they change over time. The results of this study will have important implications for the prevention, diagnosis, and treatment of age-related hearing and cognitive disorders
Detailed description
The aim of the study is to identify the early perceptual and cognitive alterations related to age-related hearing loss or presbycusis, establish a correlation between the degree of hearing loss and the deterioration of cognitive functions, and examine the effectiveness of hearing loss management in reversing observed cognitive impairments. This project has the potential to shed light on the importance of early detection of hearing impairments in preventing cognitive decline. The data collected from this cohort, rigorously assessed for both auditory and cognitive functions, could serve as the basis for several high-level scientific investigations.
Interventions
DIAGNOSTIC_TESTauditory level
* Evaluation of auditory thresholds through audiometric tests. * Evaluation of speech comprehension in noise through a vocal audiometry test in noise (FraMatrix). * Evaluation of spatial auditory behavior and spatial precision using a spatial discrimination test (Minimum Audible Angle) and a static sound localization test in virtual reality.
DIAGNOSTIC_TESTcognitive level
* Evaluation of attention and short-term memory functions with verbal and non-verbal tasks: Digit Span Test and Reading Span Test. * Evaluation of inhibition capacities using the Stroop Test. * Evaluation of executive functions, visual attention, reasoning, and mental arithmetic using the Raven's Matrix test.
DIAGNOSTIC_TESTquality of life level
\- Evaluation of quality of live level via Speech, Spatial and Qualities of Hearing Scale (SSQ-12) and EuroQol-5D questionnaires.
Sponsors
University Hospital, Toulouse
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
45 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* Normal hearing (Pure Tone Audiometry \< or = 20 dB) * Residency in one of the three neighborhoods : * Affiliation with a social security system
Exclusion criteria
* Individuals under guardianship, trusteeship or curators * History of neurological pathologies * Taking of psychotropic medication.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pure-ton audiometry | 5 years | Pure-tone audiometry will be evaluated by collecting the threshold in air and bone conduction for both ears on each frequency tested (125-250-500-1000-2000-4000 and 8000 Hz), as well as the average hearing loss (MAP ) on all five frequencies. |
Countries
France
Contacts
Primary ContactMathieu Marx, Pr
Backup ContactMariam ALZAHER, Dr
Outcome results
None listed