Interference by Activated Protein C Resistance in the Determination of Protein S Activity

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06182501

Acronym

Enrollment

9470

Registered

2023-12-27

Start date

2022-07-01

Completion date

2023-12-31

Last updated

2023-12-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Resistance to Activated Protein C in the Determination of Protein S Activity

Keywords

protein C, protein S, activated protein C

Brief summary

Protein S is an anticoagulant protein and a cofactor of protein C. It is recommended to explore it first by a functional (chronometric) technique by assessing its cofactor activity of activated protein C. Existing tests measure the prolongation of a coagulation time. These tests are all dependent on factor V, but some patients have mutations in factor V (including V Leiden) that make them resistant to activated protein C activity. It is suspected that these mutations lead to underestimations of protein S activity by chronometric technique.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Inclusion criteria

* Patient of legal age (≥ 18 years) * Patient for whom a sample has been sent to the HUS Hematology Laboratory for measurement of protein S activity between 28/12/2009 and 29/12/2020 * Patient who does not object to the reuse of his/her medical data for scientific research purposes.

Exclusion criteria

* Minor patient * Patient with incomplete data

Design outcomes

Primary

Measure	Time frame
Functional test protein C resistance	Through study completion, an average of 2 months

Countries

France

Contacts

Primary ContactAgathe HERB, MD, PhD

agathe.herb@chru-strasbourg.fr33 3 88 12 75 53

Outcome results