Sarcopenia
Conditions
Keywords
Sarcopenia, Functional magnetic stimulation
Brief summary
The goal of this clinical randomized trial is to test whether an integrated care involving peripheral functional magnetic stimulation and nutritional supplement is beneficial in population with age-related sarcopenia, as compared to usual care.
Detailed description
We will recruit participants with sarcopenia or possible sarcopenia. The participants will be divided into 2 groups. One group, the integrated care group, will receive both the peripheral functional magnetic stimulation to both the upper and lower limbs and nutritional supplement for consecutive 8 weeks. The other group, the usual care group, will receive an educational digital versatile disc (DVD) and a handbook for exercise suggestions on sarcopenia. We will compare before and after the intervention about the body composition, handgrip strength, 5-time chair stand test, 6-meter walk, and blood test for C-reactive protein and other cytokines related to sarcopenia. The participant's nutritional condition, activity level, life quality will also be analyzed via questionnaires before and after the intervention.
Interventions
DEVICEPeripheral functional magnetic stimulation (ISKRA MEDICAL TESLA Former prestige Magneto therapy)
The peripheral functional magnetic stimulation will be conducted 30 minutes a session, 2 sessions per week, for consecutive 8 weeks. The stimulation will be placed over bilateral forearm flexor muscles and bilateral thighs over rectus femoris muscles.
DIETARY_SUPPLEMENTNutritional supplementation (ENSURE HIGH CALCIUM)
The nutritional supplementation includes 7 cans of ENSURE HIGH CALCIUM per week for 8 consecutive weeks.
BEHAVIORALEducation
The education includes a DVD and one session of oral instructions on general care and exercise suggestions for sarcopenia.
Sponsors
National Taiwan University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
65 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* Age from 65 to 90 * Can walk independently for over 15 minutes * Diagnosed with possible sarcopenia or sarcopenia (by Asian Working Group for Sarcopenia: 2019 Consensus Update onSarcopenia Diagnosis and Treatment)
Exclusion criteria
* Cognitive impairment * History of cerebrovascular disease * Deep vein thrombosis * Malignancy under treatment * Coagulopathy * Serious orthopedic condition over limbs * Inability to walk independently without assistive device * Any other conditions not suggested to performance exercise * Medical implants (e.g. pacemaker, defibrillator, deep brain nerve stimulation, infusion pump, etc.)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Body composition | Before the intervention, and 1-2 weeks after the 8-week intervention | We use dual energy x-ray absorptiometry to evaluate the muscle mass (kg/m2) in the subjects. |
| Handgrip strength | Before the intervention, and 1-2 weeks after the 8-week intervention | We use a dynamometer to measure the handgrip strength (kg) |
| 5-time chair stand test | Before the intervention, and 1-2 weeks after the 8-week intervention | We measure the time of a subject to transfer from a seated to a standing position and back to sitting five times. |
| 6-meter walk | Before the intervention, and 1-2 weeks after the 8-week intervention | We measure the time of a subject to walk with the usual speed straightly for 6 meters. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Leg circumference | Before the intervention, and 1-2 weeks after the 8-week intervention | We measure the largest calf circumference with seated position with knee flexed in 90 degrees. |
| Life quality | Before the intervention, and 1-2 weeks after the 8-week intervention | We use the EuroQol-5 dimensions (EQ-5D) and Taiwan Short Form-36 questionnaires to evaluate the subjects' health life quality. |
| Cytokines related to sarcopenia | Before the intervention, and 1-2 weeks after the 8-week intervention | We will check the concentrations of cytokines including the c-reactive protein from our subjects. |
| Nutritional status | Before the intervention, and 1-2 weeks after the 8-week intervention | We use the questionnaire Mini Nutritional Assessment to evaluate the subjects' nutritional status. |
| Activity level | Before the intervention, and 1-2 weeks after the 8-week intervention | We use the International Physical Activity Questionnaire to evaluate the subjects' activity levels. |
Countries
Taiwan
Contacts
Primary ContactShao-Yu Chi
Outcome results
None listed