2015-Metabolomics&Microbiome-infertility

Microbiome and Metabolomics Analysis in a Population of Infertile Patients Suffering From Non-obstructive Azospermia and Examination of Their Impact on the Reproductive Potential and Global Health of the Individual

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06181851

Enrollment

Registered

2023-12-26

Start date

2016-06-01

Completion date

2026-05-31

Last updated

2023-12-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Azoospermia, Nonobstructive

Brief summary

Detailed description

The study aims to carry out a translational analysis of the microbiome and metabolomics in patients suffering from non-obstructive azoospermia, with the aim of investigating prognostic factors predictive of the possible finding of spermatozoa following testicular pulp extraction and differences in blood and seminal level with the fertile population to identify etiopathogenic pathways of this condition. Furthermore, the study aims to assess if the blood and seminal alterations of infertile patients have similarities with the same fluids of elderly patients, validating from a metabolomic and microbiomic point of view the hypothesis of premature aging of infertile patients.

Interventions

OTHERAnalysis of microbiome and metabolomics

Analysis of microbiome and metabolomics through the assessment of blood and semen parameters

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

MALE

Age

18 Years to 75 Years

Inclusion criteria

* diagnosis of idiopathic non-obstructive azoospermia * fertile men (pregnancy within 12 months from the start of the couple's search) * men known to have been fertile aged between 65 and 75 (pregnancy within 12 months of the couple starting searching)

Exclusion criteria

* diagnosis of varicocele * endocrine alterations * chromosomal alterations * known genetic alterations

Design outcomes

Primary

Measure	Time frame	Description
Prognostic role of the blood and semen samples	Baseline	Metabolomics and microbiome signature fertile and infertile men predicting possible finding of spermatozoa

Countries

Italy

Contacts

Primary ContactAndrea Salonia, MD

salonia.andrea@hsr.it02 2643 5661

Backup ContactAlessia d'Arma, MSc

darma.alessia@hsr.it02 2643 5506

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026