Advanced Chronic Liver Disease
Conditions
Brief summary
The goal of this observational study is to assess non-invasive tools' efficacy in predicting portal hypertension-related complications in individuals with advanced chronic liver disease. The main question it aims to answer are: \- what are the cut-off values for non-invasive tests (NITs) (including LSM, SSM) that predict the presence and occurrence of hepatic decompensation in individuals with advanced chronic liver disease? Participants will undergo regular study visits involving non-invasive tests (LSM, SSM) and assessments to monitor hepatic decompensation over the study period.
Interventions
None listed
Sponsors
McGill University Health Centre/Research Institute of the McGill University Health Centre
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age above 18years old * Advanced chronic liver disease (defined as LSM ≥ 10kPa) * Ability to provide informed consent
Exclusion criteria
* Transjugular intrahepatic portosystemic shunt * previous liver transplantation * Abnormality of the porto-mesenteric system (portal vein thrombosis, splenic vein thrombosis, splenectomy, portal cavernomatous transformation, porto-caval shunts) * Hematological malignancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of patients diagnosed with portal hypertension using elastography techniques | At baseline | We will assess the diagnostic accuracy of liver and spleen stiffness measurements for portal hypertension |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Identifying patients at high-risk of liver related events using elastography techniques | 5 years | We will use liver and spleen stiffness measurements to identify patients at risk of developing liver -related events |
Countries
Canada
Contacts
CONTACTAmine Benmassaoud, MD
CONTACTOlivia Geraci, BSc
Outcome results
None listed