Alzheimer Disease
Conditions
Brief summary
The aim of this study is to understand regional variations in acetylcholine esterase activity in Alzheimer's disease. In this study the aim is to identify by PET the physiological values of the regional activity of acetylcholine esterase using the 11C PM4 tracer and to study by PET and 11C PM4 the brain activity of acetylcholine esterase in a group of patients with Alzheimer's disease, enrolled according to the inclusion and exclusion criteria. The PET data will be correlated with the clinical, neuropsychological and morphological data acquired by MRI and with the clinical-cognitive outcome.
Interventions
DIAGNOSTIC_TESTPET with 11C MP4
Each subject will undergo a PET exam using 11C MP4 as a tracer. This is a specific ligand for the acetyl-choline esterase enzyme already used abroad both in healthy volunteers and in various patient groups.
Sponsors
IRCCS San Raffaele
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Inclusion criteria
* patients diagnosed with Alzheimer's disease; * patients must have undergone an instrumental morphological examination to exclude other neurological pathologies.
Exclusion criteria
* positive history of major head trauma; * clinically active somatic diseases.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| PET with 11C MP4 as a tracer to identify acetylcholine esterase values in patients with neurodegenerative diseases. | 4 years | Development of a new PET method for the in vivo measurement of acetylcholine esterase activity at the cortical level to be used as an indicator of the presence of disease. |
Outcome results
None listed