Fertility Issues
Conditions
Brief summary
This prospective study is subject to approval of institutional medical research ethics committee. Patient undergoing second cycle IVF will be enrolled into the intervention group. Intervention involved using a clinical decision support tool, Opt-IVF to guide gonadotrophins dosing and trigger dates for a personalized controlled ovarian stimulation cycle based on the distribution of follicle sizes on day 1 and day 5, and hormone dosages given on day 1 to 4. Patients will undergo transvaginal ultrasound exam on day 1 and day 5 of the cycle to determine the number and size of follicles present. The data is used in the Opt-IVF decision support tool to suggest Gonadotropin dosage for D5 and beyond and to recommend the antagonist start day and trigger day. Clinical investigators will not override the Opt-IVF recommended dosage in any patients.
Detailed description
The total dosage of gonadotrophin, number of good quality oocytes and blastocyst will be analyzed from each arm.
Interventions
OTHERtotal cumulative gonadotrophin usage
total dosage in IU
Sponsors
National University of Malaysia
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* Patient undergoing 2nd cycle of IVF
Exclusion criteria
* Polycystic ovarian syndrome patient
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| total cumulative dosage of Gonadotropins | for 1 year duration | number of total dosage that utilize during one cycle of IVF treatment |
| Total number of matured oocytes | for 1 year duration | number of matured oocytes following the stimulation protocol |
| total number of good quality blastocyst | for 1 year duration | total blastocyst achieved after each sti,ulation protocol |
Countries
Malaysia
Contacts
Primary ContactMuhammad Azrai Abu
Outcome results
None listed