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Investigation of Neurophysiological Functioning During Oral Comprehension Task

Investigation of Neurophysiological Functioning During Oral Comprehension Task. An Exploratory Study in Second Language (Italian) Learning in French Students Using Autonomic and Cerebral Investigation

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT06178276
Acronym
COraIL
Enrollment
70
Registered
2023-12-20
Start date
2024-02-14
Completion date
2026-02-28
Last updated
2024-02-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Comprehension, Language, Learning

Keywords

Language Learning, Oral comprehension, autonomic activity, brain activity

Brief summary

The oral comprehension (OC) of a second language (L2) involves different cognitive processes, specially during the learning phase. This study aims at investigating the neurophysiological functioning of different steps involved in this oral understanding.

Detailed description

Here, the investigators seek for the different neurophysiological processes involved in OC according to the level of understanding (2 levels) and its different phases (fluid, hindered and metacognitive feedback). This study therefore requires three different research methodologies : 1. an interactive system dedicated to the boundary delimitations of obstacles during OC 2. an investigation of the autonomic nervous system responses (measurement of electrodermal activity and heart rate variability) that will likely occur differently during different phases of the OC process 3. an investigation of the central responses (through fMRI technique), coupled with autonomous responses, that will identify the different neural networks in the different stages of the OC process.

Interventions

DIAGNOSTIC_TESTbehavior

behavioral measurements will be performed during the oral comprehension testing

DIAGNOSTIC_TESTphysiology

physiologic (autonomic) measurements will be performed during the oral comprehension testing

DIAGNOSTIC_TESTimaging

central (brain) measurements will be performed during the oral comprehension testing

Sponsors

University Grenoble Alps
CollaboratorOTHER
Institut National de la Santé Et de la Recherche Médicale, France
CollaboratorOTHER_GOV
University Hospital, Grenoble
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
CROSS_SECTIONAL

Eligibility

Sex/Gender
ALL
Age
18 Years to 35 Years
Healthy volunteers
Yes

Inclusion criteria

* French learner in Italian language * right-handed * affiliated to French social security * informed consent signed

Exclusion criteria

* pregnant woman * audiologic pathology impacting the capacity of hearing * neurologic or psychiatric pathology that may interfere with oral comprehension * learning disability (for instance: dyslexia) * contra-indication to MRI and to EDA acquisition

Design outcomes

Primary

MeasureTime frameDescription
Sympathetic activityup to 3 months following the language profile completionElectroDermal Activity (EDA) measured in µS

Secondary

MeasureTime frameDescription
Activated brain regions demonstrating brain activityup to 6 months following the language profile completionfMRI brain imaging data will be analyzed using Statistical Parametric Mapping (SPM12).
Correlations between sympathetic and parasympathetic activityup to 3 months following the language profile completioncorrelation between EDA components measured in µS and relative power of the HF-HRV
Interaction between sympathetic activity and brain activityup to 6 months following the acquisition of language profileCorrelation of EDA (µS) with fMRI brain imaging data
Parasympathetic activityup to 3 months following the language profile completionHeart Rate Variability (HRV) measured using the relative power of the high-frequency (HF) component of the HRV (in % of the total power)
Linguistic evaluationup to 1 month following the acquisition of language profileLinguistic processes are assessed by performance score on the following tests: verbal fluency test in first language (number of items found in 1 min) verbal fluency test in second language (number of items found in 1 min)
Cognitive evaluation of executive functionsup to 1 month following the acquisition of language profileCognitive evaluation assessed by the following tests: Trail Making Test (TMT-A and TMT-B) scores. Time duration (in seconds) for each subtest. Shortest duration meaning efficient executive functions
Cognitive evaluation of short term memoryup to 1 month following the acquisition of language profileWAIS4 subtest (measured by scores)
Interaction between parasympathetic activity and brain activityup to 6 months following the acquisition of language profileCorrelation of relative HF component of HRV with the fMRI brain imaging data

Countries

France

Contacts

Primary ContactChantal M Delon-Martin, PhD
chantal.delon@univ-grenoble-alpes.fr+33 4 56 52 05 89
Backup ContactMonica Masperi, PhD
monica.masperi@univ-grenoble-alpes.fr+33 4 76 82 77 48

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026