Hyaluronic Acid Gel in Ridge Preservation

Efficacy of Hyaluronic Acid Gel in Ridge Preservation After Tooth Extraction: A Randomized Controlled Clinical Trial With Radiographic and Histomorphometric Study

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06176937

Enrollment

Registered

2023-12-20

Start date

2021-10-13

Completion date

2022-08-20

Last updated

2023-12-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hyaluronic Acid Gel for Preservation the Extraction Socket

Keywords

hopeless anterior tooth, atraumatic extraction, hyaluronic acid gel

Brief summary

hyaluronic acid gel applied at the extraction socket after extraction immediately to preserve the socket from post extraction resorption. hyaluronic acid has ability for osteogenesis and new bone formation.

Detailed description

twenty-four patients with one hopeless tooth at least, first CBCt before extraction to evaluate the dimension of the socket, then atraumatic extraction of the tooth to preserve the bony wall of the socket, after extraction and curettage the socket applied hyaluronic acid gel inside the socket and applied collagen membrane to secure the socket. After 4 months of extraction, CBCt was done to evaluate the dimension of the socket and the effect of hyaluronic acid. Furthermore, The core biopsy was taken by trephine bur at the time of implant placement for evaluate the histological appearance of the bone to evaluate the secondary outcome. then after three months the crown was delivered as a prosthetic part.

Interventions

DRUGHyaluronic acid

Alveolar ridge preservation by atraumatic tooth extraction and socket curettage then application hyaluronic acid gel after extraction and covering the socket by collagen membrane.

OTHERempty socket

Alveolar ridge preservation by atraumatic tooth socket without application any drug but just covering the socket by collagen membrane.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

20 Years to 50 Years

Healthy volunteers

Inclusion criteria

1. Healthy adult patients as evidenced by Burkett's oral medicine health history questionnaire 2. Both genders. 3. Age from 20 -50 years old. 4. Having at least one hopeless teeth indicated for extraction. 5. Esthetic zone teeth (anterior or premolar). 6. Sockets type 1 or 2 . 7. Patient should agree to sign a written consent after the nature of the study will be explained. \-

Exclusion criteria

1- Smokers. 2- Pregnant and breast-feeding females. 3- Mentally retarded Patients. 4- Prisoners and handicapped patients. 5- Patients with malocclusion. \-

Design outcomes

Primary

Measure	Time frame	Description
clinical outcome	baseline(before extraction)/ four months later after extraction	measurement clinical bone width of the socket by millimeter before and 4 months after extraction ...
Radiographic measurement	baseline(before extraction)/ four months later after extraction	Radiographic measurement of bone width by CBCt before and 4 months after extraction

Secondary

Measure	Time frame	Description
histological analysis	after 4 months of extraction at the time of implant placement.	The bone biopsy will be taken by trephine bur. And evaluate bone quality.
histomorphometric analysis	after 4 months of extraction at the time of implant placement.	The bone biopsy will be taken by trephine bur. And evaluate bone quantity.

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026