Cardiac CT Angiography in Patients With Acute Ischemic Stroke

Assessment of Cardiac CT Angiography in Patients Undergoing Thrombectomy for Ischemic Stroke

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06176872

Acronym

ACUTE

Enrollment

165

Registered

2023-12-20

Start date

2024-01-01

Completion date

2027-01-01

Last updated

2023-12-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Ischemic Stroke, Coronary Artery Disease

Keywords

Computed Tomography Angiography

Brief summary

Mortality rates after acute ischemic stroke remain high despite continuously improving treatment. In this context, it is important to note that a relevant portion of acute ischemic stroke patients die from adverse cardiovascular events, such as myocardial infarction, rather than from complications associated with the stroke itself. A possible reason might be that this patient group often suffers from at least moderate asymptomatic coronary artery disease. This study seeks to integrate cardiac computed tomography angiography into the standard-of-care diagnostic protocol of acute ischemic stroke. The aim of this prospective mono-centric trial is to enable accurate diagnosis of therapy-relevant coronary artery disease, other concomitant cardiac findings and cardiac causes of acute ischemic stroke, without delaying stroke therapy. In the long-run, the goal is to investigate whether cardiac computed tomography angiography and the resulting therapeutic measures (interventions or medications added) can improve functional outcome and rate of adverse cardiac complications in patients with acute ischemic stroke compared to a retrospective matched-cohort of patients without cardiac CT imaging.

Interventions

DIAGNOSTIC_TESTCardiac Computed Tomography Angiography

Non-invasive imaging of the heart, the greater vessels and the coronary arteries using computed tomography.

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

40 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients aged 40 years or above, presenting at the Emergency Department of the University Medical Center Hamburg-Eppendorf with a suspected acute ischemic stroke and a relevant neurological deficit (NIHSS score \> 4).

Exclusion criteria

* A causal differential diagnosis for the acute stroke syndrome with absent intracranial vessel occlusion. * No correlation for the patients' symptoms in the cranial CTA (no vessel obstruction).

Design outcomes

Primary

Measure	Time frame	Description
Diagnosis of therapy-relevant CAD and concomitant cardiac findings resulting in new therapeutic measurements.	1 day at hospital discharge	Number of (newly) prescribed medications (e.g., anticoagulants), cardiac diagnostics/interventions/planned interventions, clinical status (NIHSS, mRs).

Secondary

Measure	Time frame	Description
The rate of adverse cardiovascular events (MACE).	90 and 365 days	rate of major adverse cardiovascular events (MACE).

Contacts

Primary ContactJennifer Erley, MD

j.erley@uke.de+4915157487213

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026